芦荟联合山茶油预防头颈部肿瘤急性放射性皮炎的随机对照试验

Effects of aloe vera combined with camellia oil in preventing acute radiation dermatitis of patients with head and neck cancers

目的 探讨芦荟联合山茶油预防头颈部肿瘤患者急性放射性皮炎的效果。方法 选择2021年12月—2023年7月在我院首次就诊的80例头颈部肿瘤患者作为研究对象,根据随机数字表法分为观察组(n=40)和对照组(n=40)。观察组采用在放疗后及临睡前涂抹芦荟联合山茶油+常规皮肤护理,对照组仅进行常规皮肤护理。结果当累积放射剂量达到30~40 Gy时,观察组和对照组均仅发生Ⅰ级急性放射性皮炎,发生率分别为12.50%、20.00%,差异无统计学意义(P>0.05)。当累积放射剂量达到60~70 Gy时,观察组和对照组急性放射性皮炎发生率分别为67.50%、90.00%,差异有统计学意义(P<0.05),其中Ⅰ级放射性皮炎发生率分别为42.50%、47.50%,Ⅱ级及以上放射性皮炎发生率分别为25.00%、42.50%。结论 预防性使用芦荟联合山茶油能显著降低头颈部肿瘤患者急性放射性皮炎发生率,具有一定的临床应用价值。

Objective To investigate the effectiveness of aloe vera combined with camellia oil in preventing acute radia-tion dermatitis of patients with head and neck cancers.Methods A total of 80 patients with head and neck cancers who were first diagnosed at the Second People’s Hospital of Huaihua betweenDecember 2021 and July 2023 were selected for the study.They were divided into the observation group(n=40)and the control group(n=40)using random number table method.Patients in the observation group were given aloe vera combined with camellia oil and conventional skin care after radiotherapy and at bedtime.Patients in the control group were only given conventional skin care.Results When the accu-mulated radiation dose reached 30~40 Gy,only grade I acute radiation dermatitis occurred in both the observation and con-trol groups,with the incidence 12.50%and 20.00%respectively(P>0.05).When the accumulated radiation dose reached 60~70 Gy,the incidence of acute radiation dermatitis was respectively 67.50%and 90.00%in the observation and control groups(P<0.05),the incidence of grade I radiation dermatitis was 42.50% and 47.50%,and the incidence of grade II and higher radiation dermatitis was 25.00% and 42.50%,respectively.Conclusion Prophylactic use of aloe vera combined with camellia oil significantly reduced the incidence of acute radiation dermatitis in patients with head and neck cancers.