注射用醋酸亮丙瑞林缓释微球联合比卡鲁胺胶囊治疗老年前列腺癌患者的效果

Effects of Leuprorelin acetate sustained-release microspheres for injection combined with Bicalutamide capsules in treatment of elderly patients with prostate cancer

目的:观察注射用醋酸亮丙瑞林缓释微球联合比卡鲁胺胶囊治疗老年前列腺癌患者的效果。方法:选取2021年2月至2023年1月该院收治的92例老年前列腺癌患者进行前瞻性研究,按照随机数字表法分为观察组与对照组各46例。对照组采用比卡鲁胺胶囊治疗,观察组在对照组基础上联合注射用醋酸亮丙瑞林缓释微球治疗,比较两组治疗总有效率、实验室指标[前列腺特异性抗原(PSA)、游离前列腺特异性抗原(f-PSA)、血管内皮生长因子(VEGF)、转化生长因子-α(TGF-α)和转化生长因子-β1(TGF-β1)]水平和不良反应发生率。结果:观察组治疗总有效率为73.91%,明显高于对照组的52.17%,差异有统计学意义(P<0.05);治疗后,两组血清PSA、f-PSA、VEGF、TGF-α和TGF-β1水平低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:注射用醋酸亮丙瑞林缓释微球联合比卡鲁胺胶囊治疗老年前列腺癌患者可提高治疗总有效率,降低实验室指标水平,效果优于单纯比卡鲁胺胶囊治疗。

Objective:To observe effects of Leuprorelin acetate sustained-release microspheres for injection combined with Bicalutamide capsules in treatment of elderly patients with prostate cancer.Methods:A prospective study was conducted on 92 elderly patients with prostate cancer admitted to this hospital from February 2021 to January 2023.According to the random number table method,they were divided into observation group and control group,46 cases in each group.The control group was treated with Bicalutamide capsules,while the observation group was treated with Leuprorelin acetate sustained-release microspheres for injection on the basis of that of the control group.The total effective rate,the laboratory indexes[prostate-specific antigen(PSA),free prostate-specific antigen(f-PSA),vascular endothelial growth factor(VEGF),serum transforming growth factor-α(TGF-α)and transforming growth factor-β1(TGF-β1)]levels and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 73.91%,which was significantly higher than 52.17%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of serum PSA,f-PSA,VEGF,TGF-αand TGF-β1 in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Leuprorelin acetate sustained-release microspheres for injection combined with Bicalutamide capsules in the treatment of the elderly patients with prostate cancer can improve the total effective rate of treatment and reduce the levels of laboratory indexes.Moreover,it is superior to single Bicalutamide capsule treatment.