地衣芽孢杆菌活菌颗粒联合常规治疗在轮状病毒肠炎患儿中的应用效果

Effects of Bacillus licheniformis granules,live combined with conventional treatment on children with rotavirus enteritis

目的:观察地衣芽孢杆菌活菌颗粒联合常规治疗在轮状病毒肠炎患儿中的应用效果。方法:回顾性分析2021年12月至2022年12月该院收治的96例轮状病毒肠炎患儿的临床资料,按治疗方法不同分为观察组和对照组各48例。对照组采用常规治疗,观察组在对照组基础上采用地衣芽孢杆菌活菌颗粒治疗,比较两组治疗总有效率、临床症状改善时间、炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、肠道菌群(双歧杆菌、乳酸杆菌、大肠杆菌)水平和不良反应发生率。结果:观察组治疗总有效率为95.83%,明显高于对照组的83.33%,差异有统计学意义(P<0.05);观察组止吐时间、退热时间、止泻时间等临床症状改善时间短于对照组,差异均有统计学意义(P<0.05);治疗后,观察组双歧杆菌和乳酸杆菌水平均高于对照组,大肠杆菌和血清IL-6、TNF-α水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:地衣芽孢杆菌活菌颗粒联合常规治疗应用于轮状病毒肠炎患儿可提高治疗总有效率,缩短临床症状改善时间,改善肠道菌群水平,以及降低炎性因子水平,效果优于单纯常规治疗。

Objective:To observe effects of Bacillus licheniformis granules,live combined with routine treatment on children with rotavirus enteritis.Methods:The clinical data of 96 children with rotavirus enteritis admitted to this hospital from December 2021 to December 2022 were retrospectively analyzed.According to different treatment methods,they were divided into observation group and control group,48 cases in each group.The control group was treated with conventional treatment,while the observation group was treated with Bacillus licheniformis granules,live on the basis of that of the control group.The total effective rate of treatment,the improvement time of clinical symptoms,the levels of inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],the levels of intestinal flora(Bifidobacterium,Lactobacillus,Escherichia coli),and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.83%,which was significantly higher than 83.33%of the control group,and the difference was statistically significant(P<0.05).The improvement time of clinical symptoms such as antiemetic time,antipyretic time and antidiarrheal time in the observation group was shorter than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of Bifidobacterium and Lactobacillus in the observation group were higher than those in the control group,the levels of Escherichia coli and the serum IL-6 and TNF-αwere lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Bacillus licheniformis granules,live combined with conventional treatment in the children with rotavirus enteritis can improve the total effective rate of treatment,shorten the improvement time of clinical symptoms,improve the levels of intestinal flora,and reduce the levels of inflammatory factors.Moreover,it is superior to single conventional treatment.