复方福尔可定口服液联合阿奇霉素治疗喘息性支气管炎患儿的效果

Effects of compound Pholcodine oral liquid combined with Azithromycin in the treatment of children with asthmatic bronchitis

目的:观察复方福尔可定口服液联合阿奇霉素治疗喘息性支气管炎患儿的效果。方法:选取2020年1月至2023年6月该院收治的72例喘息性支气管炎患儿进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各36例。对照组采用阿奇霉素治疗,观察组在对照组基础上联合复方福尔可定口服液治疗。比较两组临床疗效,临床症状(喘息、发热、咳嗽)消失时间和住院时间,治疗前后肺功能指标(呼吸功、气道阻力、气道峰压)水平,炎性因子[白细胞介素-6(IL-6)、降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)]水平及不良反应发生率。结果:观察组治疗总有效率为97.22%(35/36),高于对照组77.78%(28/36),差异有统计学意义(P<0.05);观察组喘息、咳嗽、发热消失时间及住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组气道峰压、呼吸功及气道阻力均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-6、hs-CRP、PCT及TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:复方福尔可定联合阿奇霉素治疗喘息性支气管炎患儿,可提高临床疗效,促进临床症状恢复,提高肺功能,减轻炎症反应,效果优于单纯阿奇霉素治疗。

Objective:To observe effects of compound Pholcodine oral liquid combined with Azithromycin in the treatment of children with asthmatic bronchitis.Methods:A prospective study was conducted on 72 children with asthmatic bronchitis admitted to this hospital from January 2020 to June 2023.They were divided into control group and observation group according to the random number table method,36 cases in each group.The control group was treated with Azithromycin,while the observation group was treated with compound Pholcodine oral liquid on the basis of that of the control group.The clinical efficacy,the disappearance time of clinical symptoms(wheezing,fever,cough)and the hospitalization time,the levels of pulmonary function indexes(respiratory function,airway resistance,airway peak pressure)before and after the treatment,the levels of inflammatory factors[interleukin-6(IL-6),procalcitonin(PCT),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.22%(35/36),which was higher than the control group of 77.78%(28/36),and the difference was statistically significant(P<0.05).The disappearance time of wheezing,cough,fever and hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the airway peak pressure,the respiratory work and the airway resistance in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,hs-CRP,PCT and TNF-αin the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Compound Pholcodine combined with Azithromycin in the treatment of the children with asthmatic bronchitis can improve the clinical efficacy,promote the recovery of clinical symptoms,improve the lung function and reduce the inflammatory response.Moreover,it is superior to single Azithromycin treatment.