加味桃红四物汤联合阿司匹林肠溶片治疗短暂性脑缺血发作患者的效果

Effects of modified Taohong Siwu decoction combined with Aspirin enteric-coated tablets in treatment of patients with transient ischemic attack

目的:观察加味桃红四物汤联合阿司匹林肠溶片治疗短暂性脑缺血发作(TIA)患者的效果。方法:选取2021年7月至2022年11月该院收治的156例TIA患者进行前瞻性研究,按照随机数字表法分为观察组与对照组各78例。对照组采用阿司匹林肠溶片治疗,观察组在对照组基础上联合加味桃红四物汤治疗,比较两组临床疗效、血液流变学指标(血浆黏度、全血高切黏度、全血低切黏度)水平、基底动脉血流速度、眩晕评定量表(DARS)评分、眩晕障碍程度测量表(DHI)评分和不良反应发生率。结果:观察组治疗总有效率为96.15%,明显高于对照组的82.05%,差异有统计学意义(P<0.05);治疗后,观察组基底动脉血流速度高于对照组,血浆黏度、全血低切黏度、全血高切黏度以及DARS、DHI评分低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:加味桃红四物汤联合阿司匹林肠溶片治疗TIA患者可提高治疗总有效率和基底动脉血流速度,降低血液流变学指标水平、DARS评分和DHI评分,效果优于单纯阿司匹林肠溶片治疗。

Objective:To observe effects of modified Taohong Siwu decoction combined with Aspirin enteric-coated tablets in treatment of patients with transient ischemic attack(TIA).Methods:A prospective study was conducted on 156 patients with TIA admitted to this hospital from July 2021 to November 2022.They were divided into observation group and control group according to the random number table method,78 cases in each group.The control group was treated with Aspirin enteric-coated tablets,while the observation group was treated with modified Taohong Siwu decoction on the basis of that of the control group.The clinical effects,the hemorheology indexes(plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity)levels,the blood flow velocity of basilar artery,the dizziness assessment rating scale(DARS)score,the dizziness handicap inventory(DHI)score,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.15%,which was significantly higher than 82.05%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the blood flow velocity of basilar artery in the observation group was higher than that in the control group,the plasma viscosity,whole blood low shear viscosity,whole blood high shear viscosity as well as the DARS and DHI scores were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Modified Taohong Siwu decoction combined with Aspirin enteric-coated tablets in the treatment of the patients with transient ischemic attack can improve the total effective rate of treatment and the blood flow velocity of basilar artery and reduce the levels of hemorheology indexes,the DARS scores and the DHI scores.Moreover,it is superior to single Aspirin enteric-coated tablets treatment.