消风汤联合丙酸氟替卡松乳膏治疗慢性湿疹患者的效果

Effects of Xiaofeng decoction combined with Fluticasone propionate cream in treatment of patients with chronic eczema

目的:观察消风汤联合丙酸氟替卡松乳膏治疗慢性湿疹患者的效果。方法:回顾性分析2022年4月至2023年4月该院收治的70例慢性湿疹患者的临床资料,按照治疗方法不同将其分为对照组和观察组各35例。对照组采用丙酸氟替卡松乳膏治疗,观察组在对照组基础上联合消风汤治疗,两组均持续治疗28 d。比较两组临床疗效,治疗前后症状严重程度[湿疹面积及严重度指数(EASI)]评分、炎性因子[γ干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)]水平、皮肤屏障功能指标[皮肤油脂(SC)、经表皮水分流失(TEWL)、角质层含水量(WCSC)]水平,以及不良反应发生率。结果:观察组治疗总有效率为94.29%(33/35),高于对照组的77.14%(27/35),差异有统计学意义(P<0.05);治疗后,观察组EASI评分低于对照组,差异有统计学意义(P<0.05);治疗后,观察组IFN-γ、TNF-α、IL-17、TEWL水平均低于对照组,SC、WCSC水平均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:消风汤联合丙酸氟替卡松乳膏治疗慢性湿疹患者可提高治疗总有效率,降低症状严重程度评分和炎性因子水平,改善皮肤屏障功能指标水平,效果优于单纯丙酸氟替卡松乳膏治疗。

Objective:To observe effects of Xiaofeng decoction combined with Fluticasone propionate cream in treatment of patients with chronic eczema.Methods:The clinical data of 70 patients with chronic eczema admitted to this hospital from April 2022 to April 2023 were retrospectively analyzed.They were divided into control group and observation group according to different treatment methods,35 cases in each group.The control group was treated with Fluticasone propionate cream,while the observation group was treated with Xiaofeng decoction on the basis of that of the control group.Both groups were treated for 28 d.The clinical efficacy,the symptom severity[eczema area and severity index(EASI)]score,the inflammatory factors[interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α),interleukin-17(IL-17)]levels,the skin barrier function index[skin oil(SC),transepidermal water loss(TEWL),stratum corneum water content(WCSC)]level before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.29%(33/35),which was higher than 77.14%(27/35)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the EASI scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IFN-γ,TNF-α,IL-17 and TEWL in the observation group were lower than those in the control group,the levels of SC and WCSC were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Xiaofeng decoction combined with Fluticasone propionate cream in the treatment of the patients with chronic eczema can improve the total effective rate of treatment,reduce the symptom severity scores and the inflammatory factor levels,and improve the levels of skin barrier function indexes.Moreover,it is superior to single Fluticasone propionate cream treatment.