血清VEGF、MIP-1α、MVD在不同病理特征肾母细胞瘤患儿中的表达水平

Expression levels of serum VEGF,MIP-1αand MVD in children with nephroblastoma with different pathological features

目的:分析血清血管内皮生长因子(VEGF)、巨噬细胞炎性蛋白-1α(MIP-1α)、微血管密度(MVD)在不同病理特征肾母细胞瘤患儿中的表达水平。方法:选取2015年1月至2023年5月该院收治的89例肾母细胞瘤患儿设为观察组,另选取同期该院89名健康体检儿童设为健康组。比较两组及不同病理特征肾母细胞瘤患儿血清VEGF、MIP-1α、MVD水平。结果:观察组血清VEGF、MIP-1α、MVD水平均高于健康组,差异有统计学意义(P<0.05);不同病理特征肾母细胞瘤患儿血清VEGF、MIP-1α、MVD水平比较,Ⅲ~Ⅳ期>I~Ⅱ期,肿瘤破裂>肿瘤未破裂,淋巴结转移>淋巴结未转移,差异均有统计学意义(P<0.05)。结论:肾母细胞瘤患儿血清VEGF、MIP-1α和MVD水平较高且与病理分期、肿瘤破裂情况、淋巴结转移情况等病理特征存在相关性。

Objective:To analyze expression levels of serum vascular endothelial growth factor(VEGF),macrophage inflammatory protein-1α(MIP-1α)and micro vascular density(MVD)in children with nephroblastoma with different pathological features.Methods:A total of 89 children with nephroblastoma admitted to this hospital from January 2015 to May 2023 were selected as the observation group,and 89 healthy children in the physical examination center of the hospital during the same period were selected as the healthy group.The serum levels of VEGF,MIP-1αand MVD were compared between the two groups and among the children with nephroblastoma with different pathological features.Results:The levels of serum VEGF,MIP-1αand MVD in the observation group were higher than those in the healthy group,and the differences were statistically significant(P<0.05).Comparison of the serum VEGF,MIP-1αand MVD levels in the nephroblastoma children with different pathological features showed that:III-IV stage>I-II stage,tumor rupture>tumor unruptured,lymph node metastasis>without lymph node metastasis,and the differences were statistically significant(P<0.05).Conclusions:The serum levels of VEGF,MIP-1αand MVD in the children with nephroblastoma are highly,and are correlated with the pathological features such as pathological stage,tumor rupture and lymph node metastasis.