地奥心血康软胶囊联合依那普利对冠心病合并心房颤动患者血压测量波动性的影响

Effect of Di'ao Xinxuekang soft capsule combined with enalapril on blood pressure measurement fluctuation in patients with coronary heart disease complicated with atrial fibrillation

目的:探讨地奥心血康软胶囊联合依那普利对冠心病合并心房颤动患者血压测量波动性的影响。方法:选取2021年1月~2021年10月就诊于九江市第一人民医院的136例冠心病合并持续性非瓣膜性心房颤动患者,计算分析包括年龄、性别、合并疾病、合并用药等参数在内的各项因素和血压波动的相关性,并就是否联合使用地奥心血康软胶囊在管理血压波动方面的价值进行探索。结果:年龄、性别、合并疾病(高血压、糖尿病、卒中、心力衰竭、高脂血症)、合并用药[血管紧张素转化酶抑制剂(ACEI)、血管紧张素受体拮抗剂(ARB)、β受体阻滞剂、钙离子通道阻滞剂(CCB)、利尿剂、抗凝药、抗血小板药、他汀]与基线水平血压波动之间的相关性差异无统计学意义(P>0.05);在将计算血压波动结点值设置为“6 mmHg”这一前提下,总体研究对象的血压波动达标率为29.4%,联药组在随访过程中的血压波动达标率呈逐渐上升趋势,单药组的血压波动达标率也呈现了波动性,单药组对应时间节点的血压波动达标率较之于联药组均偏低。结论:地奥心血康软胶囊与血压管理具有良好的相关性且能够降低血压的波动性,可以考虑联合依那普利作为降压控压方案。

Objective To explore the effect of Di'ao Xinxuekang soft capsule combined with enalapril on blood pressure measurement fluctuation in patients with coronary heart disease complicated with atrial fibrillation.Method 136 patients with coronary heart disease complicated with persistent non valvular atrial fibrillation treated in Jiujiang No.1 people's Hospital from January 2021 to October 2021 were selected to calculate and analyze the correlation between various factors including age,gender,combined diseases,combined medication and blood pressure fluctuation,and to explore the value of Di'ao Xinxuekang soft capsule in managing blood pressure fluctuation.Results There was no significant correlation between two group on the comprision on age,sex,combined diseases(hypertension,diabetes,stroke,heart failure,hyperlipidemia),combined medication(ACEI,ARBβ-receptor blockers,CCB,diuretics,anticoagulants,antiplatelet drugs and statins)and baseline blood pressure fluctuation(P>0.05);On the premise that the node for calculating blood pressure fluctuation value was set to"6 mmHg",the standard rate of blood pressure fluctuation of the overall research subjects was 29.4%.The standard rate of blood pressure fluctuation in the combined drug group shows a gradual upward trend during the follow-up,and the standard rate of blood pressure fluctuation in the single drug group also shows volatility,The compliance rate of blood pressure fluctuation at the corresponding time point in the single drug group was lower than that in the combined drug group.Conclusion Di’ao Xinxuekang soft capsule has a good correlation with blood pressure management and can reduce the volatility of blood pressure.It can be considered to combine enalapril as a depressurization and pressure control plan.