草酸艾司西酞普兰联合重复经颅磁刺激治疗抑郁症的效果分析

Effect Analysis of Escitalopram Oxalate Combined with Repeated Transcranial Magnetic Stimulation in Treatment of Depression

目的:探讨草酸艾司西酞普兰联合重复经颅磁刺激治疗抑郁症的效果。方法:选取2022年1-10月联勤保障部队大连康复疗养中心收治的抑郁症患者120例作为研究对象,以随机数字表法分为对照组和观察组,各60例。对照组采用草酸艾司西酞普兰片治疗,观察组在对照组基础上实施重复经颅磁刺激治疗。比较两组抑郁症状、自杀意念及认知功能。结果:治疗前,两组贝克抑郁量表(BDI)和自杀意念量表(SSI)评分比较,差异无统计学意义(P>0.05);治疗后,两组BDI和SSI评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组即刻记忆、视觉广度、语言功能、注意、延时记忆评分比较,差异无统计学意义(P>0.05);治疗后,两组即刻记忆、视觉广度、语言功能、注意、延时记忆评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:草酸艾司西酞普兰联合重复经颅磁刺激治疗抑郁症的效果显著,可缓解患者的抑郁症状,降低自杀意念强度,改善患者的认知功能。

Objective:To explore the effect of escitalopram oxalate combined with repeated transcranial magnetic stimulation in the treatment of depression.Methods:A total of 120 patients with depression admitted to Dalian Rehabilitation and Recuperation Center of Joint Logistic Support Force from January 2022 to October 2022 were selected as the study subjects.They were divided into the control group and the observation group according to random number table method,with 60 cases in each group.The control group was treated with escitalopram oxalate tablets,and the observation group was treated with repeated transcranial magnetic stimulation on the basis of the control group.Depressive symptoms,suicidal ideation and cognitive function were compared between the two groups.Results:Before treatment,there was no significant difference in the scores of Beck Depression Inventory(BDI)and Scale for Suicidal Ideation(SSI)between the two groups(P>0.05);after treatment,the scores of BDI and SSI in the two groups were lower than those before treatment,the scores in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the scores of immediate memory,visual breadth,language function,attention and delayed memory between the two groups(P>0.05);after treatment,the scores of immediate memory,visual breadth,language function,attention and delayed memory in the two groups were higher than those before treatment,the scores in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:Escitalopram oxalate combined with repeated transcranial magnetic stimulation has a significant effect in the treatment of depression,which can alleviate depressive symptoms,reduce the intensity of suicidal ideation,and ameliorate cognitive function.