左氧氟沙星联合替硝唑治疗慢性阑尾炎的效果分析

Analysis on Effect of Levofloxacin Combined with Tinidazole in Treatment of Chronic Appendicitis

目的:探讨左氧氟沙星联合替硝唑治疗慢性阑尾炎的效果。方法:选取2017年3月-2021年3月济南市莱芜区羊里街道社区卫生服务中心收治的慢性阑尾炎患者100例作为研究对象,随机分为观察组和对照组,各50例。对照组采用替硝唑治疗,观察组在对照组基础上应用左氧氟沙星治疗。比较两组临床疗效、炎性因子水平、淋巴细胞水平。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.042)。治疗前,两组C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)水平比较,差异无统计学意义(P>0.05);治疗后,两组CRP、TNF-α、IL-8水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组CD4^(+)、CD8^(+)水平比较,差异无统计学意义(P>0.05);治疗后,两组CD4^(+)水平均高于治疗前,且观察组高于对照组,两组CD8^(+)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:左氧氟沙星联合替硝唑治疗慢性阑尾炎的效果显著,可减轻炎性反应,提升患者免疫力。

Objective:To explore the effect of levofloxacin combined with tinidazole in the treatment of chronic appendicitis.Methods:A total of 100 patients with chronic appendicitis treated in Jinan City Laiwu District Yangli Street Community Health Service Center from March 2017 to March 2021 were selected as the study subjects.They were randomly divided into observation group and control group,with 50 patients in each group.The control group was treated with tinidazole and the observation group was treated with levofloxacin on the basis of the control group.The clinical efficacy,inflammatory factors and lymphocyte levels were compared between the two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.042).Before treatment,there was no significant difference in the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-8(IL-8)between the two groups(P>0.05);After treatment,the levels of CRP,TNF-αand IL-8 in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in CD4^(+)and CD8^(+)levels between the two groups(P>0.05);After treatment,the CD4^(+)levels in the two groups were higher than those before treatment,and the levels in the observation group were higher than those in the control group;the CD8^(+)levels in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:Levofloxacin combined with tinidazole has a significant effect in the treatment of chronic appendicitis,and can reduce inflammatory reactions and improve the immunity of patients.