三黄膏防治化疗性静脉炎的临床效果分析

Clinical Effect Analysis of Sanhuang Plaster in Prevention and Treatment of Chemotherapy-Induced Phlebitis

目的:探讨三黄膏防治化疗性静脉炎的临床效果。方法:选取2021年1月—2023年3月榆林市中医医院收治的200例化疗患者作为研究对象,采用随机数字表法分为对照组和观察组,各100例。对照组接受水胶体敷料贴敷,观察组接受三黄膏治疗。比较两组化疗性静脉炎发生率、化疗性静脉炎中医症状积分、治疗总有效率、血清指标水平。结果:观察组化疗性静脉炎发生率低于对照组,差异有统计学意义(P=0.001)。观察组化疗性静脉炎中医症状积分低于对照组,差异有统计学意义(P=0.044)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.032)。用药前,两组化疗性静脉炎患者C反应蛋白(CRP)、血管内皮生长因子(VEGF)、肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05);治疗后,对照组化疗性静脉炎患者CRP、TNF-α水平高于用药前,且高于同时期观察组,VEGF水平低于用药前,且低于同时期观察组,差异有统计学意义(P<0.05)。结论:三黄膏防治化疗性静脉炎的效果显著,可降低化疗性静脉炎发生率,并改善化疗性静脉炎患者临床症状及血清指标。

Objective:To explore the clinical effect of Sanhuang Plaster in the prevention and treatment of chemotherapy-induced phlebitis.Methods:A total of 200 patients undergoing chemotherapy in Yulin Hospital of Traditional Chinese Medicine between January 2021 and March 2023 were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 100 cases in each group.The control group was treated with hydrocolloid dressing,and the observation group was treated with Sanhuang Plaster.The incidence of chemotherapy-induced phlebitis,TCM symptom scores of chemotherapy-induced phlebitis,total effective rate and serum index levels were compared between the two groups.Results:The incidence of chemotherapy-induced phlebitis in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.001).The TCM symptom score of chemotherapy-induced phlebitis in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.044).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.032).Before medication,there was no significant difference in the levels of C-reactive protein(CRP),vascular endothelial growth factor(VEGF)and tumor necrosis factor-α(TNF-α)between the two groups(P>0.05);After treatment,the levels of CRP and TNF-αin the control group were higher than those before medication and higher than those in the observation group during the same period,and the VEGF levels in the control group were lower than those before medication and lower than those in the observation group,with a statistically significant difference(P<0.05).Conclusion:Sanhuang Plaster has a significant effect in the prevention and treatment of chemotherapy-induced phlebitis,and can reduce the incidence of chemotherapy-induced phlebitis and improve the clinical symptoms and serum indexes of patients with chemotherapy-induced phlebitis.