免疫细胞研究和细胞治疗与自身免疫病

Immunocellular research and cellular therapy in autoimmune diseases

通过介绍单细胞技术在自身免疫疾病研究中的应用,突出其在细胞异质性分析中的重要作用。阐述了单细胞转录组测序、单细胞免疫组库测序、单细胞转座酶可及染色质(ATAC)测序等关键技术,并探讨它们在免疫细胞分析和疾病治疗研究中的潜力。此外,还探讨了自身免疫疾病的发病机制、遗传和环境因素,以及细胞治疗方法包括干细胞治疗、免疫细胞治疗和基因修饰细胞治疗。强调细胞治疗在自身免疫疾病治疗中的潜力和挑战,探索了未来发展的可能方向。

By introducing the application of single-cell technology in the research of autoimmune diseases,this article highlights its crucial role in the analysis of cellular heterogeneity.Key technologies such as single-cell transcriptome sequencing,single-cell immune repertoire sequencing,and single-cell sequencing assay for transposase-accessible chromatin sequencing are elucidated.The potential of these techniques in the analysis of immune cells and research on disease treatment is discussed.Additionally,the article explores the pathogenesis of autoimmune diseases,encompassing genetic and environmental factors.It delves into cellular treatment methods,including stem cell therapy,immune cell therapy,and gene-modified cell therapy.The article emphasizes the potential and challenges of cellular therapy in the treatment of autoimmune diseases and explores possible directions for future development.