多烯磷脂酰胆碱联合甘草酸二铵治疗老年脂肪肝患者的效果及对炎症因子的影响

Effect of polyene phosphatidylcholine combined with diammonium glycyrrhizinate on elderly patients with fatty liver and its influence on inflammatory factors

目的研究多烯磷脂酰胆碱联合甘草酸二铵治疗老年脂肪肝患者的效果及对炎症因子的影响。方法回顾性分析82例老年脂肪肝患者的临床资料,根据用药方案不同分为对照组(41例)和观察组(41例)。对照组采用多烯磷脂酰胆碱治疗,观察组采用多烯磷脂酰胆碱联合甘草酸二铵治疗。比较两组临床疗效及治疗前后血脂功能指标[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、炎症因子[血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、肝功能指标[谷草转氨酶(AST)、谷丙转氨酶(ALT)]。结果两组治疗后TC、TG、LDL-C均较治疗前下降,HDL-C均较治疗前上升,且观察组TC(4.30±0.65)mmol/L、TG(1.38±0.25)mmol/L、LDL-C(2.13±0.38)mmol/L均较对照组的(5.09±0.78)、(1.74±0.31)、(2.61±0.46)mmol/L低,HDL-C(1.48±0.18)mmol/L较对照组的(1.24±0.11)mmol/L高(P<0.05)。两组治疗后TNF-α、IL-6均较治疗前下降,且观察组TNF-α(21.44±4.23)ng/L、IL-6(10.36±2.38)ng/L均低于对照组的(29.79±3.34)、(18.02±2.69)ng/L(P<0.05)。两组治疗后ALT、AST均较治疗前下降,且观察组ALT(42.56±6.51)U/L、AST(38.86±4.69)U/L均低于对照组的(63.91±7.89)、(58.02±5.92)U/L(P<0.05)。观察组总有效率95.12%高于对照组的80.49%(P<0.05)。结论多烯磷脂酰胆碱联合甘草酸二铵治疗老年脂肪肝的疗效显著,可协同改善脂代谢和肝功能,减轻炎症反应,利于受损肝组织修复,促进疾病转归。

Objective To study the effect of polyene phosphatidylcholine combined with diammonium glycyrrhizinate on elderly patients with fatty liver and its influence on inflammatory factors.Methods The clinical data of 82 elderly patients with fatty liver were retrospectively analyzed.They were divided into a control group(41 cases)and observation group(41 cases)according to different medication schemes.The control group was treated with polyene phosphatidylcholine,and the observation group was treated with polyene phosphatidylcholine and diammonium glycyrrhizinate.The clinical efficacy,lipid function indexes[total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)]and inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],liver function indicators[aspartate transaminase(AST),alanine aminotrasferase(ALT)]before and after treatment.Results After treatment,TC,TG and LDL-C were decreased and HDL-C was increased in both groups compared with those before treatment;and TC of(4.30±0.65)mmol/L,TG of(1.38±0.25)mmol/L and LDL-C of(2.13±0.38)mmol/L in the observation group were lower than those of(5.09±0.78),(1.74±0.31)and(2.61±0.46)mmol/L in the control group;HDL-C of(1.48±0.18)mmol/L was higher than that of(1.24±0.11)mmol/L in the control group(P<0.05).After treatment,TNF-αand IL-6 in both groups were decreased compared with those before treatment,and TNF-αand IL-6 in the observation group[(21.44±4.23)ng/L and(10.36±2.38)ng/L]were lower than those in the control group[(29.79±3.34)and(18.02±2.69)ng/L](P<0.05).After treatment,ALT and AST in both groups were lower than those before treatment,and ALT of(42.56±6.51)U/L and AST of(38.86±4.69)U/L in the observation group were lower than those of(63.91±7.89)and(58.02±5.92)U/L in the control group(P<0.05).The total effective rate of 95.12%in the observation group was higher than that of 80.49%in the control group(P<0.05).Conclusion Polyene phosphatidylcholine combined with diammonium glycyrrhizinate is effective in the treatment of senile fatty liver,which can synergistically improve lipid metabolism and liver function,reduce inflammatory reaction,help repair damaged liver tissue,and promote disease prognosis.