门诊老年阴道炎患者采用替硝唑栓联合雌二醇凝胶治疗疗效观察

Clinical observation of tinidazole suppository combined with estradiol gel in the treatment of senile vaginitis in outpatient department

目的观察门诊老年阴道炎患者采用替硝唑栓联合雌二醇凝胶治疗疗效。方法200例老年阴道炎患者,以随机数字表法分为对照组和观察组,每组100例。对照组给予替硝唑栓治疗,观察组给予替硝唑栓联合雌二醇凝胶治疗。对比两组患者的治疗效果、临床症状发生情况、雌激素[卵泡刺激素(FSH)、雌二醇(E2)]水平以及不良反应发生情况。结果观察组治疗总有效率99.00%高于对照组的89.00%(P<0.05)。治疗后,对照组患者的阴道壁红肿出血、白带多、阴道瘙痒、阴道灼热发生率分别为36.00%、39.00%、28.00%、29.00%,观察组分别为10.00%、8.00%、10.00%、5.00%,与对照组患者的阴道壁红肿出血、白带多、阴道瘙痒、阴道灼热发生率对比,观察组更低(P<0.05)。治疗后,与对照组患者的FSH(14.37±3.11)U/L、E2(98.43±6.99)pmol/L对比,观察组的FSH(23.29±4.22)U/L、E2(151.88±7.84)pmol/L更高(P<0.05)。两组患者不良反应发生率对比无差异(P>0.05)。结论在门诊老年阴道炎患者治疗中应用替硝唑栓联合雌二醇凝胶治疗具有较佳的临床效果,患者的临床症状得到了明显改善,雌激素水平增高,具有较高的治疗安全性,值得临床应用。

Objective To observe the therapeutic effect of tinidazole suppository combined with estradiol gel on senile vaginitis in outpatient department.Methods 200 elderly vaginitis patients were divided into a control group and an observation group by random number table,with 100 cases in each group.The control group was treated with tinidazole suppository,and the observation group was treated with tinidazole suppository combined with estradiol gel.The treatment effect,clinical symptoms,estrogen[follicle stimulating hormone(FSH),estradiol(E2)]level,and occurrence of adverse reactions of the two groups were compared.Results After treatment,the total effective rate of treatment in the observation group(99.00%)was higher than that in the control group(89.00%)(P<0.05).After treatment,the incidence of vaginal wall redness,swelling and bleeding,excessive vaginal discharge,vaginal itching,and vaginal burning in the control group were 36.00%,39.00%,28.00%and 29.00%,while those in the observation group were 10.00%,8.00%,10.00%and 5.00%,respectively.Compared with the control group,the incidence of vaginal wall redness,swelling and bleeding,excessive vaginal discharge,vaginal itching,and vaginal burning was lower in the observation group(P<0.05).After treatment,the observation group had FSH of(23.29±4.22)U/L and E2 of(151.88±7.84)pmol/L were higher than those of(14.37±3.11)U/L and(98.43±6.99)pmol/L in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of tinidazole suppository and estradiol gel has a better clinical effect in the treatment of senile vaginitis in outpatient department.The clinical symptoms of patients have been significantly improved,the estrogen level has increased,which has a higher therapeutic safety and is worthy of clinical application.