二地鳖甲煎汤联合六味地黄软胶囊治疗勃起功能障碍肾阴虚证患者的临床疗效分析

Clinical effect analysis of Erdi Biejiajian Decoction combined with Liuwei Dihuang Soft Capsule in treating erectile dysfunction patients with kidney Yin deficiency syndrome

目的 探究应用二地鳖甲煎汤联合六味地黄软胶囊治疗勃起功能障碍(ED)肾阴虚证患者的临床疗效。方法 80例勃起功能障碍肾阴虚证患者,采用计算机随机分为观察组和对照组,每组40例。观察组患者应用二地鳖甲煎汤联合六味地黄软胶囊治疗,对照组患者口服安慰剂颗粒。比较两组患者治疗前后的勃起功能国际问卷(IIEF-5)评分、主要症状以及次要症状积分、血清性激素指标[促黄体生成素(LH)、催乳素(PRL)、睾酮(T)、卵泡刺激素(FSH)、雌二醇(E2)]。结果 治疗8周后,观察组IIEF-5评分为(20.96±4.12)分,对照组为(15.30±3.48)分,与对照组相比,观察组IIEF-5评分显著提升(P<0.05)。治疗8周后,观察组主要症状以及次要症状积分分别为(2.16±0.63)、(7.96±1.45)分,对照组分别为(3.26±0.45)、(10.36±3.58)分,与对照组相比,观察组主要症状以及次要症状积分显著下降(P<0.05)。治疗8周后,观察组FSH、LH、T、E2、PRL水平分别为(2.22±0.54)mIU/ml、(1.06±0.26)mIU/ml、(25.86±4.65)ng/dl、(38.65±4.54)ng/L、(11.04±3.47)ng/ml,对照组分别为(4.81±1.11)mIU/ml、(2.85±0.44)mIU/ml、(20.99±4.19)ng/dl、(58.79±6.16)ng/L、(11.18±3.18)ng/ml,与对照组相比,观察组FSH、LH、E2水平显著下降, T水平显著提升(P<0.05);两组患者的PRL水平相比无明显差异(P>0.05)。结论 应用二地鳖甲煎汤联合六味地黄软胶囊治疗勃起功能障碍肾阴虚证患者效果显著,可明显改善患者的勃起情况、主要症状以及次要症状、血清性激素指标,值得应用。

Objective To explore the clinical effect of Erdi Biejiajian Decoction combined with Liuwei Dihuang Soft Capsule in treating erectile dysfunction(ED)patients with kidney Yin deficiency syndrome.Methods 80 cases of erectile dysfunction patients with kidney Yin deficiency syndrome were randomly divided into an observation group and a control group by computer,with 40 cases in each group.The observation group was treated with Erdi Biejiajian Decoction combined with Liuwei Dihuang Soft Capsule,and the control group was treated with placebo granule.Comparison was made on scores of the International Index of Erectile Function-5(IIEF-5),scores of major symptoms and minor symptoms,and serum sex hormone indexes[luteinizing hormone(LH),prolactin(PRL),testosterone(T),follicle stimulating hormone(FSH),estradiol(E2)]before and after treatment between the two groups.Results After 8 weeks of treatment,the IIEF-5 score of the observation group was(20.96±4.12)points,and that of the control group was(15.30±3.48)points.Compared with the control group,the IIEF-5 score of the observation group was significantly improved(P<0.05).After 8 weeks of treatment,the scores of major symptoms and minor symptoms in the observation group were(2.16±0.63)and(7.96±1.45)points,and those in the control group were(3.26±0.45)and(10.36±3.58)points,respectively.Compared with the control group,the scores of major symptoms and minor symptoms in the observation group were significantly decreased(P<0.05).After 8 weeks of treatment,the levels of FSH,LH,T,E2 and PRL in the observation group were(2.22±0.54)mIU/ml,(1.06±0.26)mIU/ml,(25.86±4.65)ng/dl,(38.65±4.54)ng/L and(11.04±3.47)ng/ml,and those in the control group were(2.85±0.44)mIU/ml,(4.81±1.11)mIU/ml,(20.99±4.19)ng/dl,(58.79±6.16)ng/L and(11.18±3.18)ng/ml.Compared with the control group,the levels of FSH,LH and E2 in the observation group were significantly decreased,and the level of T was significantly increased(P<0.05).There was no significant difference in PRL level between the two groups(P>0.05).Conclusion The application of Erdi Biejiajian Decoction combined with Liuwei Dihuang Soft Capsule in the treatment of erectile dysfunction patients with kidney Yin deficiency syndrome has remarkable effect,which can significantly improve the erectile condition,major symptoms and minor symptoms,and serum sex hormone indexes.It is worthy of application.