血清miR-501和miR-195与局部晚期宫颈癌患者同步放化疗敏感性的关系

Relationship between serum miR-501 and miR-195 levels and sensitivity to concurrent chemoradiotherapy in patients with locally advanced cervical cancer

目的探讨局部晚期宫颈癌(LACC)患者血清miR-501和miR-195与同步放化疗敏感性的关系。方法回顾性分析2020年1月—2022年6月河南省南阳市中心医院收治的96例LACC患者,与同期96例健康体检者对照,比较两者血清miR-501和miR-195的差异。于患者同步放化疗6个月后复查肿瘤情况,以实体瘤疗效评定标准将患者分为敏感组和抵抗组。采用单因素和多因素分析血清miR-501和miR-195与局部晚期宫颈癌患者同步放化疗敏感性的关系,并绘制受试者操作特征(ROC)曲线预测LACC患者同步放化疗敏感性的区分效能。多因素分析采用二元logistic回归分析,P<0.05为差异有统计学意义。结果LACC患者的血清miR-501表达水平显著高于健康体检者,miR-195表达水平显著低于健康体检者(P<0.05)。单因素分析显示,抵抗组患者入院时血清miR-501表达水平显著高于敏感组,miR-195表达水平显著低于敏感组(P<0.05)。多因素分析显示,血清miR-501、miR-195表达水平与LACC患者同步放化疗敏感性显著相关,ROC曲线的曲线下面积分别为0.736、0.913。结论LACC患者治疗前的血清miR-501表达水平越高、miR-195表达水平越低,同步放化疗抵抗概率越高。患者治疗前的血清miR-501和miR-195表达水平对同步放化疗敏感性具有一定的预测价值。

Objective To investigate the relationship between serum miR-501 and miR-195 levels and sensitivity to concurrent chemoradiotherapy in patients with locally advanced cervical cancer(LACC).Methods Clinical data of 96 patients with LACC admitted to Nanyang Central Hospital from January 2020 to June 2022 were retrospectively analyzed and compared with those of 96 healthy subjects during physical examination in our hospital during the same period to compare the differences of serum miR-501 and miR-195 levels.Tumor status was reviewed at 6 months after concurrent chemoradiotherapy.Patients were divided into the sensitive and resistant groups according to the evaluation criteria of solid tumor efficacy.The relationship between serum miR-501 and miR-195 levels and the sensitivity to concurrent chemoradiotherapy in LACC patients was analyzed by univariate and multivariate analyses.The receiver operating characteristic(ROC)curve was also drawn to predict differential efficacy of concurrent chemoradiotherapy sensitivity in LACC patients.Multivariate analysis was conducted by binary logistic regression analysis.P<0.05 indicated statistically significant differences.Results In LACC patients,serum miR-501 level was significantly higher,whereas serum miR-195 level was significantly lower than those in physical examination subjects(both P<0.05).Univariate analysis showed that serum miR-501 level at admission in the resistant group was significantly higher,whereas serum miR-195 level was significantly lower than those in the sensitive group(both P<0.05).Multivariate analysis showed that serum miR-501 and miR-195 levels were significantly correlated with the sensitivity to concurrent chemoradiotherapy in LACC patients.The area under the ROC curve(AUC)was 0.736 and 0.913,respectively.Conclusions The higher the serum miR-501 level and the lower the serum miR-195 level before treatment,the higher the probability of resistance to concurrent chemoradiotherapy in LACC patients.Serum miR-501 and miR-195 levels of LACC patients before treatment have certain predictive value for the sensitivity to concurrent chemoradiotherapy.