基于数据挖掘探讨王旭高治疗痰饮病用药规律

Discussion on the medication law of Wang Xugao for the treatment of phlegm-drinking disease based on data mining

目的基于数据挖掘技术探讨《王旭高临证医案》治疗痰饮病的组方思路,分析王旭高辨治痰饮病的用药规律。方法以《王旭高临证医案》所载《痰饮》《痰喘》《肝风痰火》篇章的医案建立数据库,采用Excel 2017软件对所有中药进行频次及性味、归经分析,对频次≥10的中药则采用IBM SPSS Modeler 18软件进行基于Apriori算法的关联规则分析、采用SPSS 25.0软件进行基于Ochiai算法的聚类分析。结果共纳入医案80个,涉及处方114首,包含中药191味,高频用药主要有茯苓、半夏、陈皮、白术、苦杏仁等;王旭高治疗痰饮病用药药性主要以温性为主,其次为寒性、平性,药味以甘、苦、辛为主,归经主要归肺、脾、胃、肝、肾经;关联规则分析得到款冬花-苦杏仁、半夏-干姜、钩藤-石决明等核心药对;聚类分析得到8组核心药物组合。结论王旭高辨治痰饮病时,注重多脏腑同治以协调脏腑间平衡,重视痰饮病兼夹寒、火、湿邪等复杂性病因,注重顾扶正气以退却邪气,调畅三焦以疏通气机。多以三焦同治、通阳化痰、清肝息风为法,用药治以甘温,佐以苦辛。

Objective To explore the prescription ideas of treating phlegm-drinking disease in Wang Xugao Lin Zheng Yi An;To analyze the medication law of Wang Xugao's clinical treatment of phlegm-drinking disease.Methods The database was established based on the medical records of the chapter of phlegm,fluid retention and liver wind and phlegm fire contained in Wang Xugao Lin Zheng Yi An.Excel 2017 software was used to analyze the frequency,taste and meridian tropism of all Chinese materia medica.For Chinese materia medica with frequency≥10,IBM SPsS Modeler 18 software was used to analyze the association rules based on Apriori algorithm,and SPsS 25.0 software was used for cluster analysis based on Ochiai algorithm.Results A total of 80 medical cases were included,involving 114 prescriptions,including 191 flavors of Chinese materia medica.High-frequency Chinese materia medica mainly included Poria,Pinelliae Rhizoma,Citri Reticulatae Pericarpium,Atractylodis Macrocephalae Rhizoma and Armeniacae Semen Amarum,etc.The main properties in Wang Xugao's medication for the treatment of phlegm-drink disease were warm,followed by cold and mild.The main tastes were sweet,bitter and pungent.Drugs mainly belong to the lung meridian and spleen,stomach,liver,kidney meridians;several core medicinal pairs were obtained,such as Farfarae Flos-Armeniacae Semen Amarum,Pinelliae Rhizoma-Zingiberis Rhizoma,Uncariae Ramulus cum Uncis-Haliotidis Concha,etc.Eight groups of core drug combinations could be sorted out by clustering analysis.Conclusions In the treatment of phlegm-drinking disease,Wang Xugao paid attention to the simultaneous treatment of multiple viscera to coordinate the balance between the viscera,emphasized the complex etiology of phlegm-drinking disease combined with cold,fire and dampness,attached importance to the treatment of healthy qi to retreat pathogens,the regulation of three-energizer to regulate qi flow.The treatment of three-energizer,promoting yang and reducing phlegm,clearing liver and dispelling wind are the main methods.Medication mainly chooses properties of sweet and warm,with bitter andpungent.