甲状腺结节与维生素D水平的相关性研究

Correlation between thyroid nodules and serum Vitamin D level

目的研究甲状腺结节与血清维生素D水平的相关性,为寻求甲状腺结节干预方法提供参考依据。方法分析167例体检者临床资料,根据甲状腺超声结果分为结节组(n=68)和对照组(n=99),比较两组生化指标及维生素D缺乏患病率,分析维生素D缺乏与甲状腺结节发生的相关性。结果与对照组相比,结节组年龄、空腹血糖、糖化血红蛋白高于对照组(P<0.05),血清25羟基维生素D(25-hydroxyvitamin D,25(OH)D)水平低于对照组(P<0.05)。与对照组相比,结节组的高血压病和糖耐量异常患病率更高(P<0.05)。单发结节组与多发结节组相比,血25(OH)D水平差异无统计学意义。超声C-TIRADS分级3类及3类以下组与分级4类及4类以上组相比,血25(OH)D水平差异无统计学意义。二元Logistic回归分析提示年龄≥40岁、维生素D缺乏、糖调节受损为甲状腺结节发生的独立危险因素(P均<0.05)。相对于维生素D正常,维生素D缺乏致甲状腺结节发生风险增加4.931倍(95%CI 1.581-15.727,P=0.001)。结论此研究中甲状腺结节患者血清维生素D水平低于健康人群。维生素D缺乏可能是引起甲状腺结节发生的危险因素。甲状腺结节与维生素D水平的相关性有待进一步研究。

Objective To study the correlation between thyroid nodules and serum Vitamin D level.Methods 167 cases of physical examination were selected and divided into nodule group(n=68)and(n=99)control group according to the results of thyroid ultrasound.The biochemical indexes and the prevalence of Vitamin D deficiency were compared between the two groups,and the correlation between Vitamin D deficiency and thyroid nodules was analyzed.Results The age,fasting blood glucose and glycosylated hemoglobin of the nodular group were significantly higher than those of the control group(P<0.05),and the level of 25(OH)D was significantly lower than that of the control group(P<0.05).Compared with the control group,the incidence of hypertension and impaired glucose regulation in the nodular group was higher(P<0.05).There was no significant difference in blood 25(OH)D between the single nodule group and the multiple nodule group.There was no significant difference in blood 25(OH)D between ultrasound C-TIRADS grade 3 and below 3 groups and grade 4 and above 4 groups.Binary logistic regression analysis showed that age≥40 years,Vitamin D deficiency,and impaired glucose regulation were independent risk factors for the occurrence of thyroid nodules(P<0.05).Compared with normal Vitamin D,Vitamin D deficiency increased the risk of thyroid nodules by 4.931 times(95%CI 1.581-15.727,P=0.001).Conclusion The serum Vitamin D level of patients with thyroid nodules is lower than that of healthy people.Vitamin D deficiency may be a risk factor for thyroid nodules.