以治疗性生活方式为导向的干预措施对双相情感障碍患者血脂水平及生活质量的影响

The impact of therapeutic lifestyle oriented interventions on blood lipid levels and quality of life in patients with bipolar disorder

目的探析以治疗性生活方式为导向的干预措施对双相情感障碍患者血脂水平及生活质量的影响。方法前瞻性分析,纳入2021年7月-2023年4月赣州市第三人民医院收治的100例双相情感障碍患者作为研究对象,随机分为对照组和观察组,每组各50例。对照组给予常规干预,观察组加用以治疗性生活方式为导向的干预措施。比较两组血脂水平(总胆固醇、甘油三酯以及高密度脂蛋白胆固醇)、血糖水平(糖化血红蛋白、空腹血糖)、生活质量[生活质量评定量表(SF-36)]以及代谢综合征发生情况。结果干预3个月,两组患者总胆固醇、甘油三酯、糖化血红蛋白、空腹血糖水平均低于干预前,且观察组各指标变化更为显著(P<0.05);干预3个月,两组患者SF-36评分均提高,且观察组提高更为明显(P<0.05);观察组发生代谢综合征2例,少于对照组的10例(χ^(2)=6.061,P<0.05)。结论以治疗性生活方式为导向的干预措施可有效调节双相情感障碍患者血脂及血糖水平,提高患者生活质量,降低代谢综合征发生风险。

Objective To explore the impact of therapeutic lifestyle oriented interventions on blood lipid levels and quality of life in patients with bipolar disorder.Method A prospective analysis was conducted,including 100 patients with bipolar disorder admitted to the hospital from July 2021 to April 2023 as the study subjects.They were randomly divided into a control group and an observation group,with 50 patients in each group.The control group received routine intervention,while the observation group received intervention measures guided by a therapeutic lifestyle.Compare the blood lipid levels(total cholesterol,triglycerides,and high-density lipoprotein cholesterol),blood glucose levels(glycated hemoglobin fasting blood glucose),quality of life[quality of life assessment scale(SF-36)],and the occurrence of metabolic syndrome between two groups.Results After 3 months of intervention,the levels of total cholesterol,triglycerides,glycated hemoglobin,and fasting blood glucose in both groups of patients were lower than before the intervention,and the changes in various indicators in the observation group were more significant(P<0.05);after 3 months of intervention,the SF-36 scores of both groups of patients improved,and the improvement was more significant in the observation group(P<0.05);there were 2 cases of metabolic syndrome in the observation group,less than 10 cases in the control group(χ^(2)=6.061,P<0.05).Conclusion Intervention measures guided by therapeutic lifestyle can effectively regulate blood lipid and glucose levels in patients with bipolar disorder,improve their quality of life,and reduce the risk of metabolic syndrome.