双抗疗法联合尤瑞克林注射液对急性脑梗死患者血管内皮功能及ADL评分的影响

The effect of dual antibody therapy combined with urinary kallidinogenase injection on vascular endothelial function and ADL score in patients with acute cerebral infarction

目的探讨双抗疗法联合尤瑞克林注射液对急性脑梗死(ACI)患者血管内皮功能及ADL评分的影响。方法选取2020年4月-2023年5月在寻乌县人民医院就诊的95例ACI患者作为研究对象,应用随机数字表法分成常规组(n=47)、观察组(n=48)。常规组给予双抗疗法治疗,观察组在其基础上给予尤瑞克林注射液治疗,治疗14d后对比两组疗效、神经功能、血管内皮功能、血液流变学指标及ADL评分。结果与常规组比较,观察组总有效率更高(P<0.05);治疗后两组NO、VEGF水平均增高,ET-1水平均降低,且相较于常规组,观察组NO、VEGF、ET-1水平改善更优(P<0.05);治疗后两组红细胞聚集指数、血浆黏度及全血黏度均降低,且相较于常规组,观察组红细胞聚集指数、血浆黏度及全血黏度更低(P<0.05);治疗后两组NIHSS评分均降低,ADL评分均增高,且相较于常规组,观察组NIHSS评分更低、ADL评分更高(P<0.05)。结论双抗疗法联合尤瑞克林注射液治疗ACI疗效确切,能改善血管内皮功能及血液流变状态,减轻神经功能缺损程度,提高日常生活能力。

Objective To investigate the effect of dual antibody therapy combined with urinary kallidinogenase injection on vascular endothelial function and ADL score in patients with acute cerebral infarction(ACI).Method 95 ACI patients who visited our hospital from April 2020 to May 2023 were selected as the study subjects and randomly divided into a conventional group(n=47)and an observation group(n=48).The conventional group was treated with dual antibody therapy,while the observation group was treated with urinary kallidinogenase injection on the basis of it.After 14 days of treatment,the efficacy,neurological function,vascular endothelial function,hemorheological indicators,and ADL score of the two groups were compared.Results The total effective rate of the observation group was higher than that of the conventional group(P<0.05);after treatment,the levels of NO and VEGF increased in both groups,while the levels of ET-1 decreased.Compared with the conventional group,the observation group showed better improvement in NO,VEGF,and ET-1 levels(P<0.05);after treatment,the red blood cell aggregation index,plasma viscosity,and whole blood viscosity of both groups decreased,and compared to the conventional group,the observation group had lower red blood cell aggregation index,plasma viscosity,and whole blood viscosity(P<0.05);after treatment,both groups had a decrease in NIHSS scores and an increase in ADL scores,and compared to the conventional group,the observation group had a lower NIHSS score and a higher ADL score(P<0.05).Conclusion The combination of dual antibody therapy and urinary kallidinogenase injection has a definite therapeutic effect on ACI,which can improve vascular endothelial function and hemorheological state,alleviate neurological deficits,and improve daily living ability.