中成药临床实践指南制定方法(六)——推荐意见形成与呈现

Methodology for the Development of Clinical Practice Guidelines for Chinese Patent Medicine(Part 6):Formation and Presentation of Recommendations

推荐意见形成是临床实践指南制定的关键环节,其应包含确定推荐的强度和方向,推荐理由及实施推荐意见的方法。推荐意见可通过正式共识法和非正式共识法形成。判定中成药临床实践指南的推荐意见强度和方向时应综合考虑中成药的证据质量、临床问题的优先性、疗效和不良反应的利弊、患者的接受度、推荐意见的可行性和资源可用性、社会公平性、经济效益等影响因素。为了更好地指导指南制定者更合理地考虑这些因素,通过结合中医药特点对每个因素进行详细的解释说明。

Recommendation formation is a key component of clinical practice guidelines for Chinese patent medicine(CPM),and should encompass the determination of the strength and direction of the recommendation,the rationale for the recommendation,and the methodology for implementing the recommendation.Recommendations can be formed through formal consensus and informal consensus.The strength and direction of recommendations for CPM guidelines should be determined by considering the quality of evidence for CPMs,the priority of the clinical questions,the pros and cons of efficacy and adverse effects,patient acceptance,the feasibility of the recommendation and the availability of resources,social fairness,economic benefits,and other influencing factors.In order to better guide guideline developers to consider these factors more rationally,this article provideed a detailed explanation of each factor in the context of the characteristics of TCM.