蛭龙血通胶囊联合长春西汀注射液治疗脑梗死恢复期的临床研究

Clinical study on Zhilong Xuetong Capsules combine with Vinpocetine Injection in treatment of convalescent cerebral infarction

目的观察蛭龙血通胶囊联合长春西汀注射液治疗脑梗死恢复期的临床效果。方法选取2018年7月—2021年4月石河子大学第一附属医院收治的121例脑梗死恢复期患者,随机数字表法将患者分为对照组(60例)和治疗组(61例)。对照组患者静脉滴注长春西汀注射液,溶于250 mL生理盐水中,初始剂量20 mg/次,视患者耐受情况逐渐加至30 mg/次,1次/d。治疗组在对照组治疗的基础上口服蛭龙血通胶囊,4粒/次,3次/d。两组均连续治疗2周。比较两组的临床疗效、量表评分、血清神经损伤指标。结果治疗后,治疗组的总有效率高于对照组(P<0.05)。治疗后,两组美国国立卫生研究院卒中量表(NIHSS)评分下降,日常生活能力量表(ADL)评分升高(P<0.05),且治疗组NIHSS评分显著低于对照组,ADL评分高于对照组(P<0.05)。治疗后,两组血清S100β蛋白、神经元特异性烯醇化酶(NSE)、心型脂肪酸结合蛋白(HFABP)水平均显著下降(P<0.05),且治疗组血清神经损伤指标水平均显著低于对照组(P<0.05)。结论蛭龙血通胶囊联合长春西汀注射液治疗脑梗死恢复期疗效较好,可促进患者日常生活能力恢复、减轻神经功能损伤。

Objective To observe the clinical effect of Zhilong Xuetong Capsules combine with Vinpocetine Injection in treatment of convalescent cerebral infarction.Methods Patients(121 cases)with convalescent cerebral infarction admitted to the First Affiliated Hospital of Shihezi University from July 2018 to April 2021 were randomly divided into control group(60 cases)and treatment group(61 cases)using a random number table method.Patients in the control group were iv administered with Vinpocetine Injection,the initial dose was 20 mg per time,dissolved in 250 mL physiological saline,gradually increasing to 30 mg/time depending on the patient's tolerance,once daily.Patients in the treatment group were orally administered Zhilong Xuetong Capsules on the basis of the control group,4 grains/time,three times daily.Patients in two groups were treated for 2 weeks.The clinical efficacies,scale scores,and serum nerve injury indicators in two groups were compared.Results After treatment,the total effective rate of the treatment group was higher than that of the control group(P<0.05).After treatment,NIHSS scores in two groups were decreased,while ADL scores in two groups were increased(P<0.05).And NIHSS score in the treatment group was significantly lower than that in the control group,while ADL score in the treatment group was higher than that in the control group(P<0.05).After treatment,the levels serum of S100β protein,NSE,and H-FABP in two groups were significantly decreased(P<0.05),and the levels of serum nerve injury indicators in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Combination of Zhilong Xuetong Capsules and Vinpocetine Injection has clinical effect in treatment of convalescent cerebral infarction,can promote the recovery of patients’daily living ability,and reduce their neurological damage.