解郁安神胶囊联合度洛西汀治疗产后抑郁症的临床研究

Clinical study on Jieyu Anshen Capsules combined with duloxetine in treatment of postpartum depression

目的探讨解郁安神胶囊联合盐酸度洛西汀肠溶片治疗产后抑郁症的临床效果。方法选取2021年8月—2023年2月河北省荣军医院收治的94例产后抑郁症患者,按照随机数字表法将94例患者分为对照组和治疗组,每组各47例。对照组口服盐酸度洛西汀肠溶片,1片/次,2次/d。治疗组患者在对照组基础上饭后口服解郁安神胶囊,4粒/次,2次/d。两组共治疗8周。比较两组的临床疗效、抑郁程度、睡眠质量、血清神经递质、血清炎性因子。结果治疗后,治疗组的总有效率比对照组总有效率高,组间比较差异显著(P<0.05)。治疗后,两组的Edinburgh产后抑郁量表(EPDS)、匹兹堡睡眠质量量表(PSQI)评分均显著降低(P<0.05),且治疗组的EPDS、PSQI评分低于对照组(P<0.05)。治疗后,两组的血清5-羟色胺(5-HT)、神经肽Y(NPY)水平显著升高(P<0.05),且治疗组的血清5-HT、NPY水平高于对照组(P<0.05)。治疗后,两组血清白细胞介素-1β(IL-1β)、γ-干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)水平显著降低(P<0.05),且治疗组血清IL-1β、IFN-γ、TNF-α水平降低程度比对照组高(P<0.05)。结论解郁安神胶囊联合盐酸度洛西汀肠溶片可提高产后抑郁症的临床疗效,有助于提高患者睡眠质量,减轻抑郁程度,调节神经递质的分泌,降低炎症反应。

Objective To investigate the clinical effect of Jieyu Anshen Capsules combined with Duloxetine Hydrochloride Entericcoated Tablets in treatment of postpartum depression.Methods Women(94 cases)with postpartum depression in Hebei Province Veterans Hospital from August 2021 to February 2023 were divided into control and treatment groups according to random number table method,and each group had 47 cases.Women in the control group were po administered with Duloxetine Hydrochloride Entericcoated Tablets,1 tablet/time,twice daily.Women in the treatment group were po administered with Jieyu Anshen Capsules on the basis of the control group after a meal,4 grains/time,twice daily.Women in two groups were treated for 8 weeks.The clinical efficacies,depression level,sleep quality,the serum levels of neurotransmitters and inflammatory factors in two groups were compared.Results After treatment,the total effective rate of the treatment group was higher than that of the control group,with significant differences between groups(P<0.05).After treatment,EPDS and PSQI scores of two groups were significantly decreased(P<0.05),and EPDS and PSQI scores of the treatment group were lower than those of the control group(P<0.05).After treatment,the serum levels of 5-HT and NPY in two groups were significantly increased(P<0.05),and the serum levels of 5-HT and NPY in the treatment group were higher than those in the control group(P<0.05).After treatment,the serum levels of IL-1β,IFN-γ,and TNF-α were significantly decreased in two groups(P<0.05),and the serum levels of IL-1β,IFN-γ,and TNF-α in the treatment group was higher than that in the control group(P<0.05).Conclusion Jieyu Anshen Capsules combined with Duloxetine Hydrochloride Enteric-coated Tablets can improve the clinical efficacy of postpartum moderate and severe depression,help to improve the sleep quality of patients,reduce the degree of depression,reduce inflammation,regulate the secretion of neurotransmitters.