摘要
Talaroclauxins A and B(1 and 2),two novel duclauxin hybrids,were obtained from Talaromyces stipitatus,along with three new(3-5)and one known analogue(6).Their structures were determined by NMR spectroscopy,HRESIMS,single-crystal X-ray diffraction,and quantum chemical calculations.Compound 1 is the first example of duclauxin-ergosterol hybrid featuring an unprecedented dodecacyclic ring system formed via a[4+2]cycloaddition,while compound 2,bearing an unusual 6/6/6/5/6/6/6/6 ring system,is a new member of the rare duclauxin-polyketide hybrid class of natural products.Plausible biosynthetic pathways for 1-6 are proposed.Compound 5 displayed moderate neuroprotective effects in glutamate sodium-induced SH-SY5Y cells.
基金
the Program for Changjiang Scholars of Ministry of Education of the People's Republic of China(No.T2016088)
the National Natural Science Foundation for Distinguished Young Scholars(No.81725021)
the National Natural Science Foundation for Excellent Young Scholars(No.81922065)
Innovative Research Groups of the National Natural Science Foundation of China(No.81721005)
the National Natural Science Foundation of China(No.82173706)
the Science and Technology Major Project of Hubei Province(No.2021ACA012)
the Research and Development Program of Hubei Province(No.2020BCA058)
the Academic Frontier Youth Team of HUST(No.2017QYTD19)
the Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College(HUST).
