肺纤维化疾病中Keap1/Nrf2/ARE相关信号通路与中药调控

Keap1/Nrf2/ARE related signaling pathway of pulmonary fibrosis diseases and its regulation by traditional Chinese medicine

肺纤维化(pulmonary fibrosis, PF)是多种因素引起的弥漫性肺间质疾病,以弥漫性肺泡炎和肺泡结构紊乱为特征。氧化应激是PF的发病机制之一,在PF病理过程中发挥着重要作用。Keap1/Nrf2/ARE信号通路是细胞内抗氧化应激的主要途径。近年来研究发现,中药提取物及复方制剂能够通过调控Keap1/Nrf2/ARE信号通路抑制或延缓氧化应激反应,降低纤维化程度,保护肺组织。本文拟就中药调控Keap1/Nrf2/ARE信号通路对PF进行干预的研究情况作一综述,以期为PF的临床靶向治疗提供参考。

Pulmonary fibrosis(PF)is a diffuse interstitial lung disease caused by many factors,characterized by diffuse alveolitis and alveolar structural disorder.Oxidative stress is one of the pathogenesis of pulmonary fibrosis and plays an important role in the pathological process of PF;the Keap1/Nrf2/ARE signaling pathway is the main pathway for intracellular oxidative stress.In recent years,studies have found that traditional Chinese herbal extracts and their polypills can inhibit or delay oxidative stress response by regulating the Keap1/Nrf2/ARE pathway,reduce the degree of fibrosis,thereby play a role in protecting the lung tissues.This paper will make a review on the research on the intervention of traditional Chinese herbs in the Keap1/Nrf2/ARE signaling pathway to PF,in order to provide a reference for the clinical targeted therapy of PF.