摘要
尽管抗逆转录病毒药物疗法显著降低了HIV感染者的死亡率,然而,癌症仍然是导致这一人群高死亡率的主要原因之一。非艾滋病定义的癌症(non-AIDS-defining cancers,NADCs)如结直肠癌(colorectal cancer,CRC)、乳腺癌和肝癌等的发病率和病死率近年来呈现出逐渐增加的趋势。在NADCs中,HIV感染合并CRC的研究受到了广泛的关注,大多数研究支持HIV感染者患CRC的风险高于一般人群,且该类患者在化疗过程中更容易出现骨髓抑制等不良反应。本文对HIV阳性CRC患者的流行病学、诊断及治疗的研究现状及进展进行综述。
Although antiretroviral therapy has significantly reduced the mortality rate among people infected with HIV.However,cancer remains one of the major causes of high mortality in this population.The incidence and mortality of non-AIDS-defining cancers(NADCs)such as colorectal cancer(CRC),breast cancer and liver cancer have shown a gradual increase in recent years.Among NADCs,the study of HIV infection combined with CRC has received extensive attention.Most studies support a higher risk of CRC in people with HIV infection comparing to the general population,and patients are more prone to adverse reactions such as myelosuppression during chemotherapy.In this article,the current status and advances in the epidemiology,diagnosis,and treatment of HIV-positive CRC patients are reviewed.
作者
汪雅婷
杨科
曾紫微
曹旭健
彭勇权
王敏
Wang Yating;Yang Ke;Zeng Ziwei;Cao Xujian;Peng Yongquan;Wang Min(Graduate Collaborative Training Base of the First Hospital of Changsha,Hengyang Medical School,University of South China,Hengyang 421001,China;Department of Infectious Diseases Surgery,the First Hospital of Changsha,Changsha 410000,China;The Institute of HIV/AIDS,the First Hospital of Changsha,Changsha 410005,China)
出处
《国际流行病学传染病学杂志》
CAS
2023年第6期422-426,共5页
International Journal of Epidemiology and Infectious Disease
基金
湖南省科学技术厅研究项目(2020SK21361)
暨南大学肿瘤分子生物学教育部重点实验室开放课题(202205)。
关键词
获得性免疫缺陷综合征
结直肠癌
流行病学
治疗
诊断
Acquired immunodeficiency syndrome
Colorectal cancer
Epidemiology
Treatment
Therapy