血栓炎症在缺血性卒中发生发展机制中的研究进展

Research progress on the mechanism of thromboinflammation in the occurrence and development of ischemic stroke

在病理条件下,血管内皮细胞功能障碍触发凝血级联反应和炎症反应过程,其中,内皮细胞、血小板、白细胞之间的接触以及众多可溶性因子对细胞的调控将两个过程密切联系起来,共同构成“血栓炎症”过程。血栓炎症广泛参与了大动脉粥样硬化型缺血性卒中的发病、卒中急性期及再灌注损伤和卒中复发。了解血栓炎症在缺血性卒中中的作用对疾病的治疗和二级预防有重大意义,本文综述了血栓炎症作用机制及其在缺血性卒中发生发展中的研究进展。

Pathologically,vascular endothelial cell dysfunction leads to coagulation cascade and inflammatory processes.They are closely linked by both physical interactions and soluble factors regulation among endothelial cells,platelets,and white blood cells.Together,they constitute the process of"thromboinflammation".Thromboinflammation significantly contributes to the pathogenesis of large artery atherosclerotic ischemic stroke,acute stroke injury,and reperfusion injury,as well as stroke recurrence.Understanding the role of thromboinflammation in ischemic stroke is of great significance for the treatment and secondary prevention of the disease.This article reviews the recent research progress on the mechanism of thromboinflammation and its role in the development of ischemic stroke.