OSAHS与NAFLD的相关性

Association between obstructive sleep apnea hypopnea syndrome and non-alcoholic fatty liver disease

阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的并发症涉及多器官、多系统,其中在消化系统方面常与非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)密切相关。尽管肥胖是OSAHS和NAFLD这两种疾病的重要危险因素,但也有研究表明,即使在没有肥胖和其他共同危险因素的情况下,OSAHS也可参与NAFLD一系列的发生发展过程。OSAHS发病机制主要与其反复发生上呼吸道狭窄或阻塞引起的间歇性缺氧(intermittent hypoxia,IH)有关。本文讨论了OSAHS与NAFLD之间的关系及其相关机制,重点讨论了IH在NAFLD发生发展中所起的作用。

The complications of obstructive sleep apnea hypopnea syndrome(OSAHS)involve multiple systems and organs,among which the digestive system is often closely related to nonalcoholic fatty liver disease(NAFLD).Although obesity is an important risk factor in both OSAHS and NAFLD,studies have shown that OSAHS is associated with the development and evolution of NAFLD even in the absence of obesity or other shared risk factors.The OSAHS-NAFLD association is related to the degree of intermittent hypoxia(IH)as a result of recurrent episodes of upper airway obstruction during sleep in OSAHS.This work discusses the association between OSAHS and NAFLD and its related mechanisms,focusing on the role of IH in the progression of NAFLD.