膜性肾病抗原与发病机制

Antigens and pathogenesis of membranous nephropathy

膜性肾病(membranous nephropathy,MN)是免疫介导的肾脏疾病,其特征是上皮下免疫沉积。目前通过利用先进的蛋白质组学技术,已经鉴定出多种靶抗原,抗原相关MN可能表现出独特的临床及病理学关联,有助于医生识别潜在病因和触发因素,如自身免疫性疾病、癌症、药物和感染等。基于抗原的方法将进一步定义MN的亚型,有望促进非侵入性诊断方法的发展。故本文就近年MN抗原、组织病理学及发病机制的研究现状作一综述。

Membranous nephropathy(MN)is an immune-mediated kidney disease characterized by subepithelial immune deposition.At present,through the use of advanced proteomics techniques,a variety of target antigens have been identified.Antigen-associated MN may show unique clinical and pathological associations,which can helps physicians to identify potential causes and triggers,such as autoimmune diseases,cancers,drugs and infections.Antigen-based approaches will further define subtypes of MN and will be expected to facilitate the development of non-invasive diagnostic methods.Therefore,this work provides a reviews of recent research on MN antigens,histopathology,and pathogenesis.