B类Ⅰ型清道夫受体基因突变与冠心病高密度脂蛋白胆固醇的相关性研究

Correlation between allele mutation of SR-BI gene and high-density lipoprotein cholesterol in the elderly with coronary heart disease

目的探讨B类Ⅰ型清道夫受体(SR-BⅠ)外显子1A等位基因突变与冠心病HDL-C的关系。方法选取2020年1月至2022年12月在武汉市第一医院心内科就诊的280例冠心病患者为观察组,纳入同期在我院体检的100例非冠心病患者为对照组。检测所有入组者SR-BⅠ外显子1的基因型和等位基因,分析冠心病的危险因素。结果观察组AA基因型和A等位基因显著高于对照组(P<0.05)。所有入组者GA+AA患者高血压、高脂血症、冠心病发病率和血脂水平显著高于未突变患者(P<0.05),HDL-C水平显著更低(P<0.05);高血压(OR=1.976,95%CI:1.093~3.571)、高脂血症(OR=2.179,95%CI:1.178~4.033)、TC(OR=2.570,95%CI:1.060~6.233)、HDL-C(OR=3.190,95%CI:1.403~7.252)、SR-BⅠ外显子1A等位基因突变(OR=2.300,95%CI:1.136~5.354)是冠心病的独立危险因素(P<0.05)。SR-BⅠ外显子1A等位基因突变与高血压、高脂血症、TC、LDL-C、Gensini积分呈正相关(r=0.441、0.530、0.418、0.292、0.547,P<0.05),与HDL-C呈负相关(r=-0.536,P<0.05)。结论SR-BⅠ外显子1A等位基因突变与HDL-C呈负相关,是冠心病发病的独立危险因素。

Objective To explore the relationship between the mutation of exon 1 A allele of scavenger receptor class B type I(SR-BI)and HDL-C.Methods A total of 280 patients with coronary heart disease(CHD)admitted in our department from January 2020 to December 2022 were recruited and served as observation group,and another 100 non-CHD individuals who taking physical examination during the same period were enrolled as control group.The genotypes and alleles of SR-BI exon 1 were detected,and the risk factors for CHD were analyzed.Results The percentage of AA genotype and A alee was significantly higher in the observation group than the control group(P<0.05).For all participants,higher proportions of hypertension and hyperlipi-demia,higher incidence of CHD onset and blood lipid level,while lower HDL-C level were observed in the GA+AA population than those without mutation(P<0.05).Hypertension (OR=1.976,95% CI:1.093-3.571),hyperlipidemia(OR=2.179,95% CI:1.178-4.033),TC(OR=2.570,95% CI:1.060-6.233),HDL-C(OR=3.190,95% CI:1.403-7.252),and SR-BI exon 1A alleee mutations(OR=2.300,95% CI:1.136-5.354)were independent risk factors for CHD(P<0.05).SR-BI exon 1A alleee mutation was positively correlated with hypertension,hyperlipi-demia,TC and LDL-C levels,and Gensini score(r=0.441,0.530,0.418,0.292,0.547,P<0.05),and negatively with HDL-C(r=-0.536,P<0.05).Conclusion The SR-BI gene exon 1A alleee mutation is negatively correlated with HDL-C,and is an independent risk factor for CHD.