治疗神经病理性疼痛新药:mirogabalin

A new drug in treatment of neuropathic pain:mirogabalin

mirogabalin是一种新型的钙离子通道调节剂,于2019年在日本获批上市用于治疗神经病理性疼痛。与普瑞巴林相比,mirogabalin可通过选择性结合电压依赖性钙离子通道α2δ-1亚单位,表现出更加长效良好的镇痛作用。多项临床试验验证了mirogabalin治疗神经病理性疼痛安全、有效,不良反应较少,患者耐受良好。

Mirogabalin is a new kind of Ca~(2+)channel regulator,approved in Japan in 2019 for the treatment of neuropathic pain.Compared with pregabalin,mirogabalin can selectively bind toα_2δ-1 subunit of voltage-gated Ca~(2+)channels,exhibiting a longer lasting and better analgesic effects.Multiple clinical trials have confirmed that mirogabalin is safe and effective in treatment of neuropathic pain with less adverse reactions and good patient tolerance.