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HSV1感染中的表观遗传调控机制研究进展 被引量:1

Advances in Epigenetic Regulatory Mechanisms inHSV1 Infection
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摘要 1型单纯疱疹病毒(HSV1)是一类最为常见的人类传染病原体,感染后可导致一系列程度不同的疾病。HSV1在中枢神经系统的潜伏感染及偶发重激活是其病理发生的关键,也为抗病毒治疗带来了巨大的挑战。目前,关于HSV1感染的建立、维持和重激活的机制并未完全阐明,但普遍认为表观遗传调控可能在其中扮演重要作用。越来越多研究表明,病毒裂解期和潜伏感染期的基因组呈现不同的染色质结构,其富含的多种翻译后修饰组蛋白赋予病毒基因转录激活或抑制特征。此外,病毒潜伏相关转录本LATs也可能参与基因组表观遗传修饰调控。 Herpes simplex viruses type 1(HSV1)is among the most ubiquitous human pathogens that cause a wide variety of disease states.The latent infection of the central nervous system and sporadically reactivation is the central part of HSV1 pathogenesis,which also brings challenges to antiviral therapies.At present,the mechanism of establishing,maintaining and reactivation of HSV1 has not been fully clarified,whereas it has been generally accepted that the epigenetic regulation may play an important role.Accumulating researches have also indicated that the lytic and latent viral genomes exhibit the different chromatin structures,and the accumulation of diverse post-translational modifies the histones endow viral genes with transcriptional activation or repression features.In addition,the latency-associate transcripts of virus may also participate in the genome epigenetic modification.In this review,we summarize the research progress of epigenetic regulation of HSV1 and highlight the critical role of chromatin remodeling in HSV1 lytic proliferation and establishment of latent infection.
作者 吴长静 邹雨芳 黄新伟 WU Changjing;ZOU Yufang;HUANG Xinwei(Central Laboratory,The 2nd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650033,China)
出处 《昆明医科大学学报》 CAS 2024年第1期172-178,共7页 Journal of Kunming Medical University
基金 国家自然科学基金资助项目(82260486)。
关键词 Ⅰ型单纯疱疹病毒 潜伏相关转录本 表观遗传调控 组蛋白翻译后修饰 Herpes simplex virus type 1 Latency associated transcripts Epigenetic regulation Post-translational modifications of histone
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