AR和HER-2在ER阴性乳腺癌中的表达及其意义

Expression and significance of AR and HER-2 in ER-negative breast cancer

目的:探讨雄激素受体(androgen receptor,AR)和人表皮生长因子受体2(human epidermal growth factor receptor 2,HER-2)在雌激素受体(estrogen receptor,ER)阴性浸润性乳腺癌中的表达及其与临床病理特征、生存期的关系。方法:收集安徽中医药大学第一附属医院病理科2018年1月至2023年2月收治的107例浸润性乳腺癌患者的临床病理资料,采用免疫组织化学方法检测AR、ER和HER-2的表达情况,对比分析ER阴性浸润性乳腺癌中AR和HER-2表达与患者年龄、肿瘤直径、组织学类型、侵袭性生物学行为、分子分型等乳腺癌临床病理特征的关系,并复习相关文献。结果:107例ER阴性浸润性乳腺癌患者中,AR阳性率为51.4%。ER阴性患者中AR与HER-2、细胞角蛋白(cytokeratin,CK)5/6及组织学分级均有关(均P<0.05)。ER阴性/HER-2阳性组中AR与CK5/6及增殖指数Ki-67均有关(均P<0.05)。ER阴性/HER-2阴性患者中,AR与增殖指数Ki-67有关(P<0.05)。生存分析显示:AR对总生存期及无病生存期均无显著影响(均P>0.05)。结论:ER阴性浸润性乳腺癌中AR与HER-2及CK5/6表达具有高度相关性,在HER-2阳性表达中AR与增殖指数Ki-67呈正相关,在HER-2阴性表达中AR与增殖指数Ki-67呈负相关,提示AR有可能成为治疗ER阴性浸润性乳腺癌的一个潜在的新靶点。

Objective:To investigate the expression of androgen receptor(AR)and human epidermal growth factor receptor 2(HER-2)in estrogen receptor(ER)-negative breast cancer and their relationship with clinical pathological characteristics and survival.Methods:Clinical pathological data of 107 patients with invasive breast cancer admitted to the Department of Pathology,the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from January 2018 to February 2023 were collected.Immunohistochemical methods were used to detect the expression of AR,ER,and HER-2 in ER-negative invasive breast cancer,and the relationship between AR and HER-2 expression and clinical pathological characteristics such as patient age,tumor diameter,histological type,invasive biological behavior,and molecular classification of breast cancer were analyzed,and related literature was reviewed.Results:Among the screened 107 ER-negative invasive breast cancer patients,the positive rate of AR was 51.4%.In ER-negative patients,AR was related to HER-2,CK5/6,and histological grade(all P<0.05).In the ER-negative/HER-2-positive patients,AR was related to CK5/6 and Ki-67 proliferation index(both P<0.05).In the ER-negative/HER-2-negative patients,AR was related to Ki-67 proliferation index(P<0.05).Survival analysis showed that AR had no significant impact on overall survival(OS)and disease-free survival(DFS).Conclusion:There is a high correlation between AR and HER-2、CK5/6 expression in ERnegative breast cancer.AR is positively correlated with Ki-67 proliferation index in HER-2-positive expression and is negatively correlated with Ki-67 proliferation index in HER-2-negative expression.This suggests that AR may be a potential new target for the treatment of ER-negative breast cancer.