糖蛋白非转移性黑色素瘤蛋白B与免疫治疗

Glycoprotein non-metastatic melanoma protein B and immunotherapy

糖蛋白非转移性黑色素瘤蛋白B(glycoprotein non-metastatic melanoma protein B,GPNMB)是一种I型跨膜蛋白,多富集在癌细胞表面,在巨噬细胞和小胶质细胞中呈高表达。GPNMB在肿瘤进展及免疫反应中发挥了重要作用,其胞外结构域与整合素相互作用,能促进免疫抑制,并能促进血管生成细胞募集到肿瘤微环境,从而影响肿瘤的免疫反应,有可能可作为免疫治疗及靶向治疗的潜在靶点。

The glycoprotein non-metastatic melanoma protein B(GPNMB)is classified as a type I transmembrane protein,predominantly localized on the surface of cancer cells,and it exhibits elevated expression levels within macrophages and microglia.GPNMB plays a crucial role in both tumor progression and immune responses.Notably,its extracellular domain interacts with integrins,thereby fostering immunosuppressive conditions and facilitating the recruitment of pro-angiogenic cells to the tumor microenvironment.This intricate interplay influences the immune response to tumors.GPNMB has the potential to serve as a target for immunotherapeutic and targeted therapeutic interventions.