H型血管促进成血管-成骨耦联在骨折愈合中作用机制的研究进展

Research Progress on the Mechanism of Type H Blood Vessels Promoting Angiogenesis-osteogenesis Coupling in Fracture Healing

骨折是临床上常见的一种骨科疾病,由此产生的骨折不愈合或延迟愈合是临床治疗的一大难题。在骨折愈合过程中,血管生成与骨生成存在复杂的相互作用关系,被称为“成血管-成骨耦联”机制。近年来,一种以高表达血小板内皮细胞粘附分子1(PECAM-1/CD31)及唾液糖蛋白内粘蛋白(EMCN)为特征的新型毛细血管亚型,即H型血管,被鉴定并发现在调控成血管-成骨耦联中起到重要的作用。该文将对H型血管促进成血管-成骨耦联的作用机制及调控H型血管新生的相关分子与信号通路进行综述,以期为促进骨折愈合提供新的思路与方法。

Fracture is a common orthopedic disease in clinical practice,and the resulting nonunion or delayed union of fractures is a major challenge in clinical treatment.In the process of fracture healing,there is a complex interaction between angiogenesis and osteogenesis,which is called the“angiogenesis-osteogenesis coupling”mechanism.In recent years,a new capillary subtype characterized by high expression of platelet endothelial cell adhesion molecule-1(PECAM-1/CD31)and salivary glycoprotein(EMCN),namely type H blood vessel,has been identified and found to play an important role in regulation of the angiogenesis-osteogenesis coupling.In this review,the mechanism of type H blood vessels promoting angiogenesis-osteogenesis coupling,the related molecules and signal pathways regulating type H blood vessels regeneration were discussed,in order to provide new ideas and methods for promoting fracture healing.