摘要
线粒体自噬在骨骼肌质量维持及功能稳态中扮演着重要角色,衰老相关线粒体自噬进程异常可能是肌肉衰减症发生发展的诱因之一。以阐述线粒体自噬的运动调节在肌肉衰减症进程中的作用及机制为主旨,分析运动介导骨骼肌线粒体自噬改善肌肉衰减症的具体过程是否有异于正常状态、如何运动效果更佳、是否需要考虑运动的联合效应等问题。对衰老进程中骨骼肌线粒体自噬状态的变化、运动影响骨骼肌线粒体自噬的作用及机制进行了系统阐述,梳理了不同运动通过调节线粒体自噬进程改善肌肉衰减症的过程、机制及效应。提出丰富可能机制、精准运动选择、联合干预方式可能是该主题基础及应用研究亟待关注的方向。
Mitophagy plays an important role in maintaining skeletal muscle mass and homeostasis.The abnormality of aging-related mitophagy may be one of the causes for the development of sarcopenia.The purpose of this study is to elucidate the role and mechanism of exercise regulated-mitophagy in the process of sarcopenia,to analyze whether the specific process of exercise mediated by mitophagy in sarcopenia is different from the normal state,how to exercise is more effective,and whether the combined effects of exercise should be considered.This study systematically elucidates the changes in skeletal muscle mitophagy during aging and the role and mechanism of exercise in affecting skeletal muscle mitophagy,the process,mechanism and effect of different exercise on ameliorating sarcopenia by regulating the process of mitophagy were reviewed.It is suggested that enriching potential mechanisms,making precise exercise choices,and considering combined interventions may be the further direction of the basic and the applied research in this topic.
作者
胡帅
武心茹
徐帅
沈飞
HU Shuai;WU Xinru;XU Shuai;SHEN Fei(Jiangsu Normal University,Xuzhou 221116,China;Kunshan Huaqiao Jishan Middle School,Suzhou 215332,China;Kunshan Integrated Traditional Chinese and Western Medicine Hospital,Suzhou 215101,China;Huaiyin Normal University,Huai’an 223300,China;Jishou University,Jishou 416000,China)
出处
《中国体育科技》
北大核心
2023年第11期82-90,共9页
China Sport Science and Technology
基金
教育部人文社会科学研究青年基金项目(22YJC890023)
高等教育学会科学研究规划课题重点项目(22TY0218)
江苏师范大学优博学位教师科研项目(21XFRX015)。
