自身免疫性肝病早期外周血RDW、ADA及补体水平的检测意义

The Significance of Early Detection of RDW,ADA,and Complement Levels in Peripheral Blood of Patients with Autoimmune Liver Disease

目的观察自身免疫性肝病患者早期外周血红细胞分布宽度(red blood cell distribution width,RDW)、腺苷脱氨酶(adenosine deaminase,ADA)及补体水平的检测意义。方法回顾性分析濮阳市安阳地区医院2019年10月至2022年10月收治的150例自身免疫性肝病患者的临床资料,将其归为观察组,再收集150例同期健康体检人群,将其归为对照组。比较两组早期外周血RDW、ADA及补体水平差异,分析患者早期外周血RDW、ADA及补体水平与自身免疫性肝病发生的相关性,采用ROC曲线分析早期外周血RDW、ADA及补体水平对自身免疫性肝病的诊断效能。结果观察组外周血RDW、ADA及补体水平均高于对照组(P<0.05)。患者早期外周血RDW、ADA及补体水平与自身免疫性肝病发生均呈正相关(P<0.05)。早期外周血RDW、ADA、ADA补体水平曲线均明显高于参考线(P<0.05),其cut-off值分别为16.61%、25.10 U/L、59.91%。结论自身免疫性肝病患者外周血RDW、ADA及补体水平明显高于正常人群,临床早期检测外周血RDW、ADA及补体水平,有利于预防自身免疫性肝病的发生,具有较高临床检测价值。

Objective To observe the significance of early detection of red blood Cell distribution width(RDW),adenosine deaminase(ADA)and complement levels in peripheral blood of patients with autoimmune liver disease.Methods The clinical data of 150 patients with autoimmune liver disease admitted to Anyang District Hospital of Puyang City from October 2019 to October 2022 were retrospectively analyzed,and they were classified into the observation group,and another 150 healthy people during the same period were collected and classified into the control group.The difference of RDW,ADA and complement levels in early peripheral blood between the two groups was compared,and the correlation between early peripheral blood RDW,ADA and complement levels and the occurrence of autoimmune liver disease was analyzed.The diagnostic efficacy of early peripheral blood RDW,ADA and complement levels in autoimmune liver disease was analyzed by ROC curve.Results The differences of RDW,ADA and complement levels in early peripheral blood of the two groups were compared,and the levels of RDW,ADA and complement in early peripheral blood of the patients and in the observation group were higher than those in the control group(P<0.05).RDW,ADA and complement levels in early peripheral blood were positively correlated with the occurrence of autoimmune liver disease(P<0.05).RDW,ADA and ADA complement levels in early peripheral blood were significantly higher than reference lines(P<0.05),and their cut off values were 16.61%,25.10 U/L and 59.91%,respectively.Conclusion The levels of RDW,ADA and complement in peripheral blood of patients with autoimmune liver disease are significantly higher than those of normal people.Early detection of RDW,ADA and complement levels in peripheral blood is helpful to prevent the occurrence of autoimmune liver disease in advance,and has high clinical detection value.