门冬胰岛素联合地特胰岛素治疗妊娠糖尿病优化分娩结局的研究

Study on Optimal Delivery Outcomes of Insulin Aspartate Combined with Insulin Detemir in the Treatment of Gestational Diabetes Mellitus

目的分析门冬胰岛素+地特胰岛素治疗妊娠糖尿病(gestational diabetes,GDM)优化分娩结局的临床效果。方法选取2022年3月—2023年3月在厦门大学附属第一医院治疗的300例GDM患者进行分析,根据随机数表法分为两组(观察组150例,对照组150例),对照组行门冬胰岛素疗法,观察组行门冬胰岛素+地特胰岛素疗法,对比两组患者治疗效果。结果观察组血糖水平优于对照组,差异有统计学意义(P<0.05),两组餐后2 h血糖对比,差异无统计学意义(P>0.05)。观察组血糖恢复时长优于对照组,观察组脂肪因子数据优于对照组,观察组患者胰岛素抵抗情况优于对照组,差异有统计学意义(P<0.05),两组胰岛素空腹水平对比,差异无统计学意义(P>0.05)。观察组患者的不良分娩结局为1.33%,对照组为2.67%,差异无统计学意义(P>0.05)。结论对GDM患者采用门冬胰岛素+地特胰岛素进行治疗,对改善患者的血糖有积极作用,可以优化其分娩结局。

Objective To analyze the clinical effect of insulin aspartate plus insulin detemir in the treatment of gesta-tional diabetes(GDM).Methods A total of 300 GDM patients treated in the First Affiliated Hospital of Xiamen Uni-versity from March 2022 to March 2023 were analyzed and divided into two groups by random number table method(150 cases in observation group and 150 cases in control group).The control group was treated with insulin aspartate,and the observation group was treated with insulin aspartate+insulin detemir.The therapeutic effect of the two groups was compared.Results The blood glucose level of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05),and there was no statistically significant difference in 2-hour post-prandial blood glucose between two groups(P>0.05).The blood glucose recovery time in the observation group was better than that in the control group,the adipokine data of the observation group was better than that of the control group,the insulin resistance of observation group was better than that of control group,and the difference was statisti-cally significant(P<0.05),while there was no statistically significant difference in fasting insulin levels between two groups(P>0.05).The adverse delivery outcome was 1.33%in the observation group and 2.67%in the control group,and the difference was not statistically significant(P>0.05).Conclusion The use of insulin aspartate+insulin detemir in the treatment of GDM patients has a positive effect on improving the blood glucose of the patients and optimizing the outcome of childbirth.