妊娠糖尿病孕妇维生素D补充治疗效果及对妊娠结局的影响

Efficacy of Vitamin D Supplementation in Pregnant Women with Gestational Diabetes Mellitus and Its Impact on Pregnancy Outcome

目的探讨妊娠糖尿病(gestational diabetes mellitus,GDM)孕妇维生素D补充治疗效果及对妊娠结局的影响。方法选取2022年6月—2023年6月徐州仁慈医院收治的48例GDM患者为研究对象,应用随机数表法分为对照组(24例,胰岛素治疗)、观察组(24例,在对照组基础上维生素D补充治疗)。比较两组母婴不良妊娠结局、空腹胰岛素、血糖及餐后2 h血糖水平。结果观察组母婴不良妊娠结局发生率4.17%,较对照组33.33%更低,差异有统计学意义(χ^(2)=4.923,P<0.05)。治疗前,两组胰岛素及血糖水平对比,差异无统计学意义(P>0.05);治疗后,观察组空腹血糖、餐后2 h血糖水平为(4.27±0.69)、(6.11±0.68)mmol/L,均较对照组的(5.11±0.72)、(6.71±0.75)mmol/L更低,空腹胰岛素水平为(8.66±1.24)mU/L,较对照组的(7.75±1.13)mU/L更高,差异有统计学意义(t=4.127、2.903、2.657,P<0.05)。结论GDM患者在胰岛素及常规干预基础上予以维生素D补充治疗,可有助于提高孕妇空腹胰岛素水平,降低血糖水平,改善妊娠结局。

Objective To investigate the effect of vitamin D supplementation in pregnant women with gestational diabetes mellitus(GDM)and its impact on pregnancy outcome.Methods 48 GDM patients admitted to Xuzhou Renren Hospital from June 2022 to June 2023 were selected as the study objects,and were divided into control group(24 cases receiving insulin treatment)and observation group(24 cases receiving vitamin D supplement treatment)by random number table method.The adverse pregnancy outcome,fasting insulin,blood glucose and 2 h postprandial blood glucose levels were compared between the two groups.Results The incidence of adverse pregnancy outcomes in the observation group was 4.17%,which was lower than that in the control group(33.33%),the difference was statistically significant(χ^(2)=4.923,P<0.05).Before treatment,there was no statistically significant difference in insulin and blood glucose levels between the two groups(P>0.05).After treatment,the fasting blood glucose and 2 h postprandial blood glucose levels in the observation group were(4.27±0.69)mmol/L,(6.11±0.68)mmol/L,which were lower than those in the control group(5.11±0.72)mmol/L,(6.71±0.75)mmol/L,and the fasting insulin level was(8.66±1.24)mU/L,compared with the control group(7.75±1.13)mU/L,the differences were statistically significant(t=4.127,2.903,2.657,P<0.05).Conclusion Vitamin D supplementation on the basis of insulin and routine intervention in GDM patients can help to increase fasting insulin level,reduce blood sugar level and improve pregnancy outcome.