观察心脉隆注射液治疗重症肺源性心脏病对不良反应造成的影响

Effects of Xinmailong Injection on the Adverse Reactions of Severe Pulmonary Heart Disease

目的评估重症肺源性心脏病采用心脉隆注射液治疗的效果和对不良反应的影响。方法选取2022年10月—2023年10月盐城市大丰中医院收治的62例重症肺源性心脏病患者为研究对象,根据掷骰子分为对照组和观察组,每组31例,对照组提供常规治疗,观察组提供心脉隆注射液治疗,比较两组治疗有效率、心功能指标及肺动脉收缩压(pulmonary artery systolic pressure,PASP)、肺动脉平均压(mean pulmonary artery pressure,MPAP)、5-羟色胺(5-hydroxy tryptamine,5-HT)水平。结果观察组治疗总有效率为96.77%,高于对照组的70.97%,差异有统计学意义(χ^(2)=7.631,P<0.05);治疗后观察组的N末端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)、血管生成素-Ⅱ(angiopoietin-2,Ang-Ⅱ)水平低于对照组,左心室射血分数(left ventricular ejection fraction,LVEF)、6 min步行距离(six minute walk distance,6-MWT)均高于对照组,差异有统计学意义(P<0.05);治疗后观察组的PASP、MPAP、5-HT均低于对照组,差异有统计学意义(P<0.05)。结论心脉隆注射液治疗效果显著,有利于改善重症肺源性心脏病疾病患者预后,可以改善患者血气指标。

Objective To evaluate the effect of Xinmailong injection on severe pulmonary heart disease and its effect on adverse reactions.Methods A total of 62 patients with severe pulmonary heart disease admitted to Dafeng Hospital of Traditional Chinese Medicine in Yancheng City from October 2022 to October 2023 were selected as the study objects and divided into control group and observation group according to dice rolling,with 31 cases in each group.The control group was provided with conventional treatment,while the observation group was provided with Xinmailong injection.The effective rate,cardiac function index,pulmonary artery systolic pressure(PASP),mean pulmonary artery pressure(MPAP)and serotonin(5-HT)level were compared between the two groups.Results The total effective rate of observation group was 96.77% higher than 70.97% of control group,and the difference was statistically significant(χ^(2)=7.631,P<0.05).After treatment,the levels of N-terminal pro-brain natriuretic peptide(NT-proBNP)and angiopoietin-2(AngⅡ)in the observation group were lower than those in the control group,the left ventricular ejection fraction(LVEF)and six minute walk distance(6-MWT)were higher than those in control group,and the differences were statistically significant(P<0.05).After treatment,the levels of PASP and MPAP and 5-HT in observation group were lower than those of control group,and the differences were statistically significant(P<0.05).Conclusion Xinmailong injection has significant therapeutic effect,which is conducive to improving the prognosis of patients with severe pulmonary heart disease and blood gas index.