老年非特殊型浸润性乳腺癌超声征象与分子生物学指标的临床研究

Clinical study of ultrasonic signs and molecular biological indicators of senile non-specific invasive breast cancer

目的探讨老年非特殊型浸润性乳腺癌(IBC-NST)超声征象与雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体-2(HER-2)、Ki67抗原等分子生物学指标表达的相关性。方法回顾性分析2017年5月至2019年8月82例经病理证实为IBC-NST患者的乳腺核磁共振检查表现(肿块大小、形态、边缘、微钙化、血流分布)及分子生物学指标。采用SPSS21.0统计学软件分析,计数资料用[例(%)]表示,采χ2检验;计量资料以()表示,采用t检验;以P<0.05为差异具有统计学意义。结果肿块大小与ER、PR、HER-2、Ki-67阳性表达相关,肿瘤边缘毛刺征与ER、PR阳性表达相关,肿块内微钙化与HER-2、Ki-67阳性表达相关(P<0.05);肿瘤形态、后方回声、血流分布与ER、PR、HER-2、Ki-67的表达均无明显相关性(P>0.05)。结论IBC-NST超声征象与分子生物学指标有明显相关性,通过分析其超声声像特征,可以评估肿瘤生物学行为,对指导临床治疗及判断预后有一定的参考价值。

Objective To investigate the correlation between ultrasound signs and the expression of estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor-2(HER-2),Ki67 antigen and other molecular biological indicators in elderly non-specific invasive breast cancer(IBC-NST).Methods The MRI findings(mass size,shape,margin,microcalcification,blood flow distribution)and molecular biological indicators of 82 patients with pathologically confirmed IBC-NST from May 2017 to August 2019 were retrospectively analyzed.SPSS21.0 statistical software was used for analysis.The counting data were represented by[n(%)]and tested.Measurement data were expressed as()and t test was adopted.P<0.05 was considered to be statistically significant.Results The tumor size was correlated with the positive expression of ER,PR,HER-2 and Ki-67,the burr sign of tumor margin was correlated with the positive expression of ER and PR,and the microcalcification in tumor was correlated with the positive expression of HER-2 and Ki-67(P<0.05).Tumor morphology,posterior echo and blood flow distribution were not significantly correlated with the expression of ER,PR,HER-2 and Ki-67(P>0.05).Conclusion IBC-NST ultrasound signs are obviously correlated with molecular biological indicators.By analyzing the ultrasonic characteristics of IBC-NST,the biological behavior of tumor can be evaluated,and it has certain reference value for guiding clinical treatment and judging prognosis.