自噬在变应性鼻炎发病的作用机制研究

Study on the role of autophagy in the pathogenesis of allergic rhinitis

自噬是一种进化上高度保守的分解代谢过程,在细胞的生长发育、机体的先天性和适应性免疫方面以及程序性细胞死亡中均发挥关键作用。近年来,自噬成为在免疫、肿瘤等各方面的研究热点,且越来越多研究证据表明自噬相关基因表达量的改变可以通过对炎症因子的调节参与过敏性炎症的发病,并可针对自噬进行相关治疗。已有新的研究表明自噬通过调节T细胞的活化与功能、影响呼吸道上皮纤维化等途径参与变异性鼻炎(allergic rhinitis,AR)的发病。AR作为一种全球性的变应性疾病,暂无有效针对性治疗方法。通过学习总结,将针对自噬对过敏性炎症的发病机制及治疗以及在AR作用进行综述,以期为自噬作为AR的诊疗靶点提供新的策略。

Autophagy is an evolutionarily highly conserved catabolic process that plays a key role in cell growth and development,innate and adaptive immunity,and programmed cell death.In recent years,autophagy has become a focus of research in the field of immunity and oncology,and there is increasing evidence that altered expression of autophagy-related genes may be involved in the pathogenesis of allergic inflammation through the regulation of inflammatory factors,and that autophagy can be targeted for treatment.New studies have shown that autophagy is involved in the pathogenesis of allergic rhinitis(AR)by regulating the activation and function of T cells and affecting respiratory epithelial fibrosis.There is no effective targeted treatment for the global allergic disease of AR.In this review,we address the role of autophagy in the pathogenesis and treatment of allergic inflammation and in the pathogenesis of AR,with the aim of providing new strategies for autophagy as a therapeutic target for AR.