摘要
HtrA丝氨酸肽酶2(HtrA serine peptidase 2,HTRA2)是一种存在于线粒体间隙的丝氨酸蛋白酶,在人类HtrA丝氨酸肽酶家族的4个成员中,HTRA2是唯一一个细胞内定位明确的蛋白酶,具有参与线粒体内稳态的维持和促进细胞凋亡的双重调节作用。HTRA2已被发现与多种肿瘤相关,同时HTRA2的表达可增强化疗与放疗的敏感性,可作为恶性肿瘤诊断、预后标志物及联合治疗的靶点。该文就HTRA2的结构、生物学功能及其在恶性肿瘤中的作用作了综述,以期为肿瘤患者的早期诊断及个体化治疗提供线索和依据。
HtrA serine peptidase 2(HTRA2)is a serine protease existing in the mitochondrial gap.Among the four members of the human HtrA serine peptidase family,HTRA2 is the only protease with clear localization in the cell.It plays a dual role in the maintenance of mitochondrial homeostasis and the promotion of cell apoptosis.HTRA2 has been found to be associated with a variety of tumors.Meanwhile,the expression of HTRA2 can enhance the sensitivity of chemotherapy and radiotherapy,and can be used as a diagnostic and prognostic marker for malignant tumors and a target for combined therapy.This article reviews the structure,biological function and role of HTRA2 in malignant tumors,in order to provide clues and basis for early diagnosis and individualized treatment of tumor patients.
作者
熊瑶
奉镭
扶长敏
颜婷
王华敏
曾秋月
XIONG Yao;FENG Lei;FU Changmin;YAN Ting;WANG huamin;ZENG Qiuyue(Graduate School of North Sichuan Medical College,Nanchong,Sichuan 637000,P.R.China;The Fifth Department of Digestive Disease Center,Suining Central Hospital,Suining,Sichuan 629000,P.R.China;Graduate School of Zunyi Medical University,Zunyi,Guizhou 563000,P.R.China)
出处
《华西医学》
CAS
2024年第1期111-116,共6页
West China Medical Journal
基金
四川省医学科研课题计划(S22028)。
