肠道菌群移植在1型糖尿病中的应用价值

Application value of fecal microbiota transplantation for type 1 diabetes mellitus

1型糖尿病(type 1 diabetes mellitus,T1DM)是胰岛β细胞被破坏后导致胰岛素绝对缺乏的自身免疫性疾病。肠道菌群及其代谢产物可通过破坏胰岛β细胞、增加胰岛素抵抗、增加肠道通透性、干扰免疫反应等方式促进T1DM的病情进展。因此肠道菌群移植在未来有望成为预防和治疗T1DM的新方法。该文主要探讨肠道菌群移植在T1DM中应用的可能途径,包括保护胰岛β细胞、改善胰岛素抵抗、降低肠道通透性、调节免疫反应。

Type 1 diabetes mellitus(T1DM)is an autoimmune disease in which pancreaticβcells are destroyed,resulting in an absolute lack of insulin.Intestinal microbiota and its metabolites can promote the progression of T1DM by destroying pancreaticβcells,increasing insulin resistance,increasing intestinal permeability,interfering with immune response.Therefore,fecal microbiota transplantation is expected to become a new method for preventing and treating T1DM in the future.This article mainly explores possible pathways for the application of fecal microbiota transplantation in T1DM,including protection of pancreaticβcells,improving insulin resistance,reducing intestinal permeability,and regulating immune responses.