不同方法改善口服清肠药口感及不良反应的研究进展

Research progress of different methods to improve the taste and adverse reactions of intestinal cleansing agents

结肠镜检查是诊断、治疗结肠疾病及早癌筛查的金标准,良好的肠道准备质量,即肠道清洁度,是结肠黏膜病变及其细节充分可视化的前提条件。临床上使用较多的口服肠道清洁剂,如聚乙二醇、硫酸镁等口感差,服药量大,部分患者不能耐受,影响肠道准备的效果。而口含辅助剂、清肠药加辅助剂、采用新型小容量或极低剂量聚乙二醇-抗坏血酸制剂等方法的出现可以降低患者恶心、呕吐等不良反应发生率,提高患者的耐受性、满意度等。该文对国内外改善清肠药口感、减轻不良反应的方法进行综述,为临床提供参考。

Colonoscopy examination is the gold standard for diagnosis and treatment of colon diseases and screening for early cancer.Good quality of bowel preparation,which is also called intestinal cleanliness,is the prerequisite for full visualization of colonic mucosal lesions and their details.In clinic,more intestinal cleansing agents,such as polyethylene glycol and magneium suifate,have bad taste and high dosage,which can not be tolerated by some patients and affect the effect of bowel preparation.The use of oral adjuvant,add adjuvant to intestinal cleansing agents,new lowvolume or very low-volume polyethylene glycol-ascorbic acid preparation methods,can reduce the incidence of adverse reactions,such as nausea and vomiting in patients,improve their tolerance,satisfaction and so on.This article reviews the methods of improving the taste and reducing the adverse reactions of intestinal cleansing agents at home and abroad to offer references for clinical practice.