毒品原植物药用研究的“负责任创新”基本策略

The Basic Strategy of"Responsible Innovation"of Medicinal Plants with Psychoactive Properties

毒品原植物具有药品和毒品双重属性,这种特殊性使其在科研创新活动中面临诸多伦理困境。立足解决国内毒品原植物医药研究面临的困境,参照负责任创新四维理论模型提出五个负责任行为框架,即政府主导为主、大众监督为辅,提倡多主体共同责任、资质认证与审查制度、全过程嵌入式伦理反思、建立负责任创新价值观和预后问责制,在提升创新动力方面提出部分性开放科学推进成果共享、创新监管机制以降低科研机构的风险。以中医药科研实践为基础,引入科学技术哲学思辨,为中医药毒品原植物科研创新规避风险,为提升创新动力提供有益思路。

Medicinal plants with psychoactive properties have both medicinal and drug attributes,which poses many ethical dilemmas in scientific research and innovation activities.This article aims to resolve the ethical dilemmas faced in the medical research of medicinal plants in China.Referring to the four-dimensional theoretical model of responsible innovation,we propose a five-fold framework for responsible conduct:primarily government-led with public supervision as a secondary measure,advocating joint responsibility among multiple entities,qualification certification and review system,embedded ethical reflection throughout the process,and establishing responsible innovation values and post-hoc accountability.To enhance the motivation for innovation,we suggest partially open science to advance result sharing and innovative regulatory mechanisms to reduce risks for research institutions.Based on the practice of Traditional Chinese Medicine research,we introduce philosophical contemplation on science and technology,providing useful insights to avoid risks in the innovative research of psychoactive medicinal plants in Traditional Chinese Medicine and to enhance the drive for innovation.