运动科学中的多组学应用前景:运动组学

Application Prospect of Multi-omics in Sports Science:Sportomics

近年来,代谢组学、蛋白质组学、转录组学、基因组学等多种组学分析技术已被应用于探究运动调控人体代谢适应的生理特征、基因特征和生物学机制,为运动相关组织器官功能和代谢状态的整体分析提供了新的思路。融合多组学、多技术的运动组学应用将成为全面解析运动应激与适应的重要手段之一,使精英运动员在不同环境、不同训练负荷下的代谢特征谱的绘制,及不同健康状况人群的运动应激与适应的全息生物图谱的构建成为可能,进而为运动员选材、训练监控、运动损伤防护提供精准指导;为不同运动方案、为精准个性化运动方案的制定提供依据。在综述运动科学领域中的组学技术应用现状的基础上,提出“运动组学”这一概念,并就运动组学的研究策略及发展前景进行总结和展望,为阐明运动应激与适应的生物学机制和构建运动代谢适应全息网络提供参考。

In recent years,a variety of omics analysis techniques,such as metabolomics,proteomics,transcriptomics and genomics,have been employed to explore the physiological and genetic features and biological mechanisms underlying the regulation of human metabolic adaptation to exercise.These adaptions present novel ideas for comprehensively analyzing the functions and metabolic states of tissues and organs associated with exercise.The application of sportomics,which integrates multi-omics and multi-technology,will become one of the important means to comprehensively analyze exercise stress and adaptation.This integration enables the mapping of the metabolic characteristic profiles of elite athletes under different conditions and different training loads,and the construction of holistic bioprofiles map of the exercise stress and adaptation in populations with diverse health conditions,thus providing precise guidance for athlete selection,training monitoring,and sports injury prevention.Moreover,it serves as a foundation for devising diverse exercise regimens and formulating precise and personalized exercise programs.On the basis of current status of omics technology applications in the field of exercise science,we put forward,the concept of “Sportomics” and summarizes the research strategies and future prospects of sportomics,which provides provide reference for elucidating the biological mechanisms of exercise stress and adaptation,as well as constructing a comprehensive network of exercise metabolism adaptation.