摘要
慢性疼痛是一种复杂的神经精神疾病,其特征是感觉、认知和情感症状。研究发现慢性疼痛与多种认知功能障碍疾病的发生发展存在密切关系。而中脑边缘多巴胺系统、蓝斑去甲肾上腺素能系统和小胶质细胞结构与功能异常在此过程中起关键作用。本文就慢性疼痛与认知功能障碍共病的发生机制进行综述。
Chronic pain is a complex neuropsychiatric disorder characterized by sensory,cognitive and emotional symptoms.Studies have found that chronic pain is closely related to the occurrence and development of a variety of cognitive disorders.The abnormal structure and function in mesencephalic limbic dopamine system,locus coeruleus norepinephrine system and microglia cells play a key role in this process.This paper reviews the mechanism of the comorbidity between chronic pain and cognitive dysfunction.
作者
雷佳钰
饶婷婷
敖婧
黄淼
王畅
彭淼
牟静
张悦
Lei Jiayu;Rao Tingting;Ao Jing;Huang Miao;Wang Chang;Peng Miao;Mou Jing;Zhang Yue(Department of Anesthesiology,Southwest Medical University,Luzhou City,Sichuan Province 646000,China;Department of Pain,Affiliated Hospital of Southwest Medical University,Luzhou City,Sichuan Province 646000,China;Department of Emergency,Affiliated Hospital of Southwest Medical University,Luzhou City,Sichuan Province 646000,China)
出处
《中华疼痛学杂志》
2023年第6期1026-1031,共6页
Chinese Journal Of Painology
基金
四川省自然科学基金(2022NSFSC1479)
国家级创新创业训练项目(202210632051)。
