MYOM2基因在临床医学和畜牧生产中的作用研究进展

Advances in the Role of MYOM2 in Clinical Medicine and Animal Production

肌间蛋白(Myomesin)基因家族分布于骨骼肌和心肌的M线中,是M线的重要连接器,主要参与肌原纤维的组装和机械力量传导,在哺乳动物中有3种亚型。肌间蛋白2(Myomesin-2,MYOM2)是Myomesin基因家族中的一员,其与骨骼肌和心肌发育有密切关系,在肌肉收缩和关节发育的过程中发挥重要作用,并与很多人类疾病的发生息息相关。MYOM2同时对畜禽肉品质改善起重要调控作用,可作为候选基因改善畜禽的肉嫩度。本文综述了MYOM2的发现过程、基因信息及其在临床医学和畜牧生产中的研究进展,为相关研究工作提供思路。

The Myomesin gene family is distributed in the M line of skeletal muscle and cardiac muscle,and is an important connector of the M line,mainly involved in the assembly of myofibrils and mechanical force conduction,and there are three subtypes in mammals.Myomesin-2(MYOM2)is a member of the Myomesin gene family,which is closely related to the development of skeletal and cardiac muscles,plays an important role in muscle contraction and joint development,and is highly associated with the occurrence of many human diseases.MYOM2 also plays an important regulatory role in the improvement of meat quality of livestock and poultry,and can be used as a candidate gene to improve the meat tenderness of livestock and poultry.This article reviews the discovery process,genetic information and research progress of MYOM2 in clinical medicine and animal husbandry production,and provides ideas for related research work.