脉络丛及其与衰老相关疾病的关系

Choroid plexus and its relations with age-related diseases

脉络丛由位于基底层上的上皮细胞组成,相邻脉络丛上皮细胞之间的紧密连接形成了血脑脊液屏障,它与血脑屏障一起对大脑微环境的稳态至关重要。脉络丛上皮可向脑室分泌脑脊液、生长因子、神经肽和脂类物质,同时脉络丛也是免疫细胞进入大脑的门户。衰老和神经退行性疾病的病理生理学仍然还存在大量未知,越来越多的研究将脉络丛与这些年龄相关性疾病的病因关联起来。本文综述了目前已知的脉络丛上皮与年龄相关疾病之间的关系,以期为防治相关疾病提供新的线索。

The choroid plexus is composed of epithelial cells situated on the basal layer.The tight junctions between adjacent choroid plexus epithelial cells establish the blood-cerebrospinal fluid barrier.This barrier,in conjunction with the blood-brain barrier,is crucial for the homeostasis of the brain microenvironment.The choroid plexus epithelium secretes cerebrospinal fluid,growth factors,neuropeptides,and lipids into the ventricles and also serves as a gateway for immune cells to enter the brain.The pathophysiology of aging and neurodegenerative diseases remains largely enigmatic,with an increasing body of research linking the choroid plexus to the etiology of these age-related disorders.In this review,we summarize the known relationship between the choroid plexus epithelium and age-related diseases,aiming to provide new therapeutic clues for these disorders.